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Sleep Quality in Neuromyelitis Optica Spectrum Disorder: A Systematic Review.
Eshtiaghi, Arshia; Eapen-John, David; Zaslavsky, Kirill; Vosoughi, Reza; Murray, Brian J; Margolin, Edward.
Afiliación
  • Eshtiaghi A; Faculty of Medicine (AE, DE-J), University of Toronto, Toronto, ON, Canada.
  • Eapen-John D; Faculty of Medicine (AE, DE-J), University of Toronto, Toronto, ON, Canada.
  • Zaslavsky K; Department of Ophthalmology and Vision Sciences (KZ, EM), University of Toronto, Toronto, ON, Canada.
  • Vosoughi R; Division of Neurology, Department of Medicine (RV, BJM), University of Toronto, Toronto, ON, Canada.
  • Murray BJ; St Michael's Hospital, Toronto, ON, Canada (RV).
  • Margolin E; Division of Neurology, Department of Medicine (RV, BJM), University of Toronto, Toronto, ON, Canada.
Int J MS Care ; 24(3): 124-131, 2022.
Article en En | MEDLINE | ID: mdl-35645625
Background: This review summarizes the literature on sleep quality in neuromyelitis optica spectrum disorder (NMOSD) and discusses these findings in the context of current knowledge of sleep physiology. Methods: A literature search was performed using Ovid MEDLINE, Embase, and Scopus from inception to September 3, 2020. All included studies reported at least 1 measure of sleep quality in individuals with NMOSD. Pittsburgh Sleep Quality Index (PSQI) scores of individuals from 4 studies were compared with those from a data set of controls. Results: Thirteen studies (1041 individuals with NMOSD) were included in the review. Disturbed sleep was demonstrated across subjective metrics based on patient surveys and objective metrics such as polysomnography. An estimated 70% of individuals with NMOSD can be classified as poor sleepers. Standardized mean difference between PSQI scores of 183 individuals with NMOSD and those of 9284 controls was 0.72 (95% CI, 0.57-0.86; P < .001). Decreased sleep quality was significantly associated with decreased quality of life and increased anxiety, depression, and disability status. Sleep disturbances in NMOSD were similar in severity to those in multiple sclerosis. Conclusions: Sleep disturbances are a major contributor to NMOSD disease burden and may arise from the disruption of sleep circuitry, in addition to physical and psychological complications. Multiple processes involved in sleep regulation may be affected, such as, but not limited to, neural circadian circuit disruption, direct effects of inflammation, aminergic projecting system abnormalities, glymphatic system impairment, and development of sleep disorders such as restless legs syndrome/sleep apnea. A better understanding of these mechanisms is necessary for developing effective therapies for NMOSD-associated sleep disturbances.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Aspecto: Patient_preference Idioma: En Revista: Int J MS Care Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Systematic_reviews Aspecto: Patient_preference Idioma: En Revista: Int J MS Care Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos