Your browser doesn't support javascript.
loading
Diazepinone HBV capsid assembly modulators.
Kuduk, Scott D; DeRatt, Lindsey G; Stoops, Bart; Shaffer, Paul; Lam, Angela M; Espiritu, Christine; Vogel, Robert; Lau, Vincent; Flores, Osvaldo A; Hartman, George D.
Afiliación
  • Kuduk SD; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States. Electronic address: skuduk@its.jnj.com.
  • DeRatt LG; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Stoops B; Janssen Pharmaceutica, NV Turnhoutseweg 30, 2340 Beerse, Belgium.
  • Shaffer P; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Lam AM; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Espiritu C; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Vogel R; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Lau V; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Flores OA; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
  • Hartman GD; Janssen Research and Development, 1400 McKean Road, Spring House, PA 19477, United States.
Bioorg Med Chem Lett ; 72: 128823, 2022 09 15.
Article en En | MEDLINE | ID: mdl-35644301
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further optimization of a progressive series of diazepinone HBV CAMs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Cápside Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Cápside Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido