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Prevalence estimation of significant fibrosis because of NASH in Spain combining transient elastography and histology.
Calleja, José L; Rivera-Esteban, Jesús; Aller, Rocío; Hernández-Conde, Marta; Abad, Javier; Pericàs, Juan M; Benito, Hugo G; Serra, Miguel A; Escudero, Amparo; Ampuero, Javier; Lucena, Ana; Sánchez, Yolanda; Arias-Loste, María T; Iruzubieta, Paula; Romero-Gómez, Manuel; Augustin, Salvador; Crespo, Javier.
Afiliación
  • Calleja JL; Department of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro, School of Medicine, Universidad Autónoma Madrid, IDIPHIM, Majadahonda, Spain.
  • Rivera-Esteban J; Liver Unit, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
  • Aller R; Universitat Autònoma de Barcelona, Bellaterra, Spain.
  • Hernández-Conde M; Department of Gastroenterology, Clinic University Hospital, Medical School, Group of Biomedical Research in Critical Care Medicine (BioCritic), University of Valladolid, Valladolid, Spain.
  • Abad J; Research Unit, Clinic University Hospital, Medical School, Institute of Health Sciences of Castille and Leon (IECSCYL), Group of Biomedical Research in Critical Care Medicine (BioCritic), Valladolid, Spain.
  • Pericàs JM; Department of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro, School of Medicine, Universidad Autónoma Madrid, IDIPHIM, Majadahonda, Spain.
  • Benito HG; Department of Gastroenterology and Hepatology, Hospital Universitario Puerta de Hierro, School of Medicine, Universidad Autónoma Madrid, IDIPHIM, Majadahonda, Spain.
  • Serra MA; Liver Unit, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
  • Escudero A; Research Unit, Clinic University Hospital, Medical School, Institute of Health Sciences of Castille and Leon (IECSCYL), Group of Biomedical Research in Critical Care Medicine (BioCritic), Valladolid, Spain.
  • Ampuero J; Digestive Medicine Service, Clinic University Hospital, University of Valencia, Valencia, Spain.
  • Lucena A; Digestive Medicine Service, Clinic University Hospital, University of Valencia, Valencia, Spain.
  • Sánchez Y; Digestive Diseases Department and CIBERehd, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.
  • Arias-Loste MT; Digestive Diseases Department and CIBERehd, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.
  • Iruzubieta P; Digestive Diseases Department and CIBERehd, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.
  • Romero-Gómez M; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain.
  • Augustin S; Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Clinical and Translational Digestive Research Group, IDIVAL, Santander, Spain.
  • Crespo J; Digestive Diseases Department and CIBERehd, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.
Liver Int ; 42(8): 1783-1792, 2022 08.
Article en En | MEDLINE | ID: mdl-35643936
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has become a major public health problem, but the prevalence of fibrosis associated with non-alcoholic steatohepatitis (NASH) is largely unknown in the general population. This study aimed to provide an updated estimation of the prevalence of NASH fibrosis in Spain. METHODS: This was an observational, retrospective, cross-sectional, population-based study with merged data from two Spanish datasets: a large (N = 12 246) population-based cohort (ETHON), including transient elastography (TE) data, and a contemporary multi-centric biopsy-proven NASH cohort with paired TE data from tertiary centres (N = 501). Prevalence for each NASH fibrosis stage was estimated by crossing TE data from ETHON dataset with histology data from the biopsy-proven cohort. RESULTS: From the patients with valid TE in ETHON dataset (N = 11 440), 5.61% (95% confidence interval [95% CI]: 2.53-11.97) had a liver stiffness measurement (LSM) ≥ 8 kPa. The proportion attributable to NAFLD (using clinical variables and Controlled Attenuation Parameter) was 57.3% and thus, the estimated prevalence of population with LSM ≥ 8 kPa because of NAFLD was 3.21% (95% CI 1.13-8.75). In the biopsy-proven NASH cohort, 389 patients had LSM ≥ 8 kPa. Among these, 37% did not have significant fibrosis (F2-4). The estimated prevalence of NASH F2-3 and cirrhosis in Spain's adult population were 1.33% (95% CI 0.29-5.98) and 0.70% (95% CI 0.10-4.95) respectively. CONCLUSIONS: These estimations provide an accurate picture of the current prevalence of NASH-related fibrosis in Spain and can serve as reference point for dimensioning the therapeutic efforts that will be required as NASH therapies become available.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico por Imagen de Elasticidad / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Europa Idioma: En Revista: Liver Int Asunto de la revista: GASTROENTEROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico por Imagen de Elasticidad / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Europa Idioma: En Revista: Liver Int Asunto de la revista: GASTROENTEROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos