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Histopathological evidence that diethylene glycol produces kidney and nervous system damage in rats.
Jamison Courtney, N; Cuevas-Ocampo Areli, K; Flowers Ashley, B; Nam Hyung, W; Dayton Robert, D; McKinney Mary, P; Mitchell Hannah, G; Fitzgerald Joseph, S; Steib Mattie, E; Toups Colton, R; McMartin Kenneth, E.
Afiliación
  • Jamison Courtney N; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • Cuevas-Ocampo Areli K; Department of Pathology, LSU Health Sciences Center, Shreveport, LA, USA.
  • Flowers Ashley B; Department of Pathology, LSU Health Sciences Center, Shreveport, LA, USA.
  • Nam Hyung W; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • Dayton Robert D; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • McKinney Mary P; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • Mitchell Hannah G; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • Fitzgerald Joseph S; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • Steib Mattie E; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • Toups Colton R; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA.
  • McMartin Kenneth E; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA, USA. Electronic address: kenneth.mcmartin@lsuhs.edu.
Neurotoxicology ; 91: 200-210, 2022 07.
Article en En | MEDLINE | ID: mdl-35643325
Diethylene glycol (DEG) is an organic compound that has been found as an adulterant in consumer products as a counterfeit glycerin. Diethylene glycol is metabolized to two primary metabolites: 2-hydroxyethoxyacetic acid (2-HEAA) and diglycolic acid (DGA), the latter shown to accumulate in the kidney and cause dose-dependent cell necrosis. DEG poisonings are characterized predominately by acute kidney injury (AKI) but have also produced delayed neurological sequelae such as sensorimotor neuropathy. To better understand these effects, Wistar-Han rats were orally administered a water control or doses of 4 g/kg-6 g/kg DEG every 12 or 24 h for 7 days, with kidney, brain, and spinal cord tissue collected for histopathological analysis. This dosing paradigm resulted in approximately 25 % of the DEG-treated animals developing AKI and also neurotoxicity (sensorimotor dysfunction and elevated cerebrospinal fluid (CSF) protein). Kidney pathology included a severe, diffuse acute kidney tubular necrosis predominantly affecting proximal convoluted tubules. Scattered birefringent crystals consistent with calcium oxalate monohydrate were also found in the proximal tubule of animals with AKI. Demyelination in the dorsal and lateral white matter regions of the cervical, thoracic, and lumbar areas of the spinal cord of a DEG-treated animal with AKI was documented, establishing the neuropathology in DEG-treated animals that developed neurotoxicity. There were significant changes in amino acid concentrations in the CSF that may reflect the neurotoxicity of DEG, specifically glutamate and glutamine, but with no ammonia change. These studies characterized the pathologic aspects of the neurotoxicity in a DEG repeat-dose model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de Neurotoxicidad / Lesión Renal Aguda Límite: Animals Idioma: En Revista: Neurotoxicology Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de Neurotoxicidad / Lesión Renal Aguda Límite: Animals Idioma: En Revista: Neurotoxicology Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos