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Positivity of Rapid Antigen Testing for SARS-CoV-2 With Serial Followed-up Nasopharyngeal Swabs in Hospitalized Patients due to COVID-19.
Kweon, Oh Joo; Lee, Joo Hee; Choi, Yang-Seon; Kim, Boo-Seop; Lim, Yong Kwan; Lee, Mi-Kyung; Park, Joung Ha; Park, Ji Young; Kim, Seong Hwan.
Afiliación
  • Kweon OJ; Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • Lee JH; Department of Pulmonary Medicine, Hyundae General Hospital, Chung-Ang University, Namyangju, Korea.
  • Choi YS; Department of Orthopaedic Surgery, Chung-Ang University Hospital, Seoul, Korea.
  • Kim BS; Department of Orthopaedic Surgery, Hyundae General Hospital, Chung-Ang University, Namyangju, Korea.
  • Lim YK; Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • Lee MK; Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  • Park JH; Department of Internal Medicine, Hyundae General Hospital, Chung-Ang University, Namyangju, Korea.
  • Park JY; Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea. jypark@caumc.or.kr.
  • Kim SH; Department of Orthopaedic Surgery, Chung-Ang University Hospital, Seoul, Korea. ksh170177@caumc.or.kr.
J Korean Med Sci ; 37(21): e168, 2022 May 30.
Article en En | MEDLINE | ID: mdl-35638195
Despite the accuracy of nucleic acid amplification tests (NAATs), rapid antigen tests (RATs) for severe acute respiratory syndrome coronavirus-2 are widely used as point-of-care tests. A total of 282 pairs of reverse transcription-polymerase chain reaction and Standard Q COVID-19 Ag tests were serially conducted for 68 patients every 3-4 days until their discharge. Through a field evaluation of RATs using direct nasopharyngeal swabs, the sensitivities were 84.6% and 87.3% for E and RNA-dependent RNA polymerase (RdRp) genes, respectively, for specimens with cycle thresholds (Cts) < 25. The Ct values of E and RdRp genes for 95% detection rates by RATs were 16.9 and 18.1, respectively. The sensitivity of RAT was 48.4% after the onset of symptoms, which was not sufficient. RAT positivity gradually decreased with increased time after symptom onset and had continuously lower sensitivity than NAATs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prueba de COVID-19 / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prueba de COVID-19 / SARS-CoV-2 / COVID-19 Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2022 Tipo del documento: Article Pais de publicación: Corea del Sur