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Retention of Neutralizing Response against SARS-CoV-2 Omicron Variant in Sputnik V-Vaccinated Individuals.
Lapa, Daniele; Grousova, Daria M; Matusali, Giulia; Meschi, Silvia; Colavita, Francesca; Bettini, Aurora; Gramigna, Giulia; Francalancia, Massimo; Garbuglia, Anna Rosa; Girardi, Enrico; Puro, Vincenzo; Antinori, Andrea; Kovyrshina, Anna V; Dolzhikova, Inna V; Shcheblyakov, Dmitry V; Tukhvatulin, Amir I; Zubkova, Olga V; Gushchin, Vladimir A; Logunov, Denis Y; Naroditsky, Boris S; Vaia, Francesco; Gintsburg, Alexander L.
Afiliación
  • Lapa D; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Grousova DM; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Matusali G; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Meschi S; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Colavita F; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Bettini A; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Gramigna G; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Francalancia M; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Garbuglia AR; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Girardi E; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Puro V; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Antinori A; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Kovyrshina AV; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Dolzhikova IV; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Shcheblyakov DV; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Tukhvatulin AI; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Zubkova OV; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Gushchin VA; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Logunov DY; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Naroditsky BS; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
  • Vaia F; INMI "National Institute of Infectious Diseases" Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy.
  • Gintsburg AL; FSBI "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya" of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.
Vaccines (Basel) ; 10(5)2022 May 21.
Article en En | MEDLINE | ID: mdl-35632574
The new Omicron variant of SARS-CoV-2, first identified in November 2021, is rapidly spreading all around the world. Omicron has become the dominant variant of SARS-CoV-2. There are many ongoing studies evaluating the effectiveness of existing vaccines. Studies on the neutralizing activity of vaccinated sera against the Omicron variant are currently being carried out in many laboratories. In this study, we have shown the neutralizing activity of sera against the SARS-CoV-2 Omicron variant compared to the reference Wuhan D614G variant in individuals vaccinated with two doses of Sputnik V up to 6 months after vaccination and in individuals who experienced SARS-CoV-2 infection either before or after vaccination. As a control to our study we also measured neutralizing antibody titers in individuals vaccinated with two doses of BNT162b2. The decrease in NtAb titers to the Omicron variant was 8.1-fold for the group of Sputnik V-vaccinated individuals. When the samples were stratified for the time period after vaccination, a 7.6-fold or 8.8-fold decrease in NtAb titers was noticed after up to 3 and 3-to-6 months after vaccination. We observed a 6.7- and 5-fold decrease in Sputnik V-vaccinated individuals experiencing asymptomatic or symptomatic infection, respectively. These results highlight the observation that the decrease in NtAb to the SARS-CoV-2 Omicron variant compared to the Wuhan variant occurs for different COVID-19 vaccines in use, with some showing no neutralization at all, confirming the necessity of a third booster vaccination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vaccines (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza