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ALCAM/CD166 Is Involved in the Binding and Uptake of Cancer-Derived Extracellular Vesicles.
Cardeñes, Beatriz; Clares, Irene; Bezos, Tamara; Toribio, Víctor; López-Martín, Soraya; Rocha, Almudena; Peinado, Héctor; Yáñez-Mó, María; Cabañas, Carlos.
Afiliación
  • Cardeñes B; Centre for Molecular Biology "Severo Ochoa" (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain.
  • Clares I; Centre for Molecular Biology "Severo Ochoa" (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain.
  • Bezos T; Centre for Molecular Biology "Severo Ochoa" (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain.
  • Toribio V; Centre for Molecular Biology "Severo Ochoa" (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain.
  • López-Martín S; Department of Molecular Biology, Faculty of Sciences, Instituto Universitario de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
  • Rocha A; Centre for Molecular Biology "Severo Ochoa" (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain.
  • Peinado H; Department of Molecular Biology, Faculty of Sciences, Instituto Universitario de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
  • Yáñez-Mó M; Centre for Molecular Biology "Severo Ochoa" (CSIC-UAM), Cell-Cell Communication & Inflammation Unit, 28049 Madrid, Spain.
  • Cabañas C; Microenvironment and Metastasis Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain.
Int J Mol Sci ; 23(10)2022 May 20.
Article en En | MEDLINE | ID: mdl-35628559
Colorectal cancer (CRC) and ovarian cancer (OvC) patients frequently develop peritoneal metastasis, a condition associated with a very poor prognosis. In these cancers, tumor-derived extracellular vesicles (EVs) cause immunosuppression, facilitate the direct attachment and invasion of cancer cells through the mesothelium, induce the conversion of peritoneal mesothelial cells (PMCs) into cancer-associated fibroblasts (CAFs) and transfer a more aggressive phenotype amongst cancer cells. Although the promoting role of EVs in CRC and OvC peritoneal metastasis is well established, the specific molecules that mediate the interactions between tumor-derived EVs and immune and non-immune target cells remain elusive. Here, we employed the SKOV-3 (ovarian adenocarcinoma) and Colo-320 (colorectal adenocarcinoma) human cell lines as model systems to study the interactions and uptake of EVs produced by ovarian carcinoma and colorectal carcinoma cells, respectively. We established that the adhesion molecule ALCAM/CD166 is involved in the interaction of cancer-derived EVs with recipient cancer cells (a process termed "EV binding" or "EV docking") and in their subsequent uptake by these cells. The identification of ALCAM/CD166 as a molecule mediating the docking and uptake of CRC and OvC-derived EVs may be potentially exploited to block the peritoneal metastasis cascade promoted by EVs in CRC and OvC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Adenocarcinoma / Antígenos CD / Moléculas de Adhesión Celular Neuronal / Proteínas Fetales / Vesículas Extracelulares Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Adenocarcinoma / Antígenos CD / Moléculas de Adhesión Celular Neuronal / Proteínas Fetales / Vesículas Extracelulares Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza