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Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results.
Palomo-López, Nora; Rodríguez-Rodríguez, Ana; Martín-Villén, Luis; Mendoza-Prieto, María; Ruiz de Azúa-López, Zaida; Sempere-Bordes, Lluis; Boyero-Corral, Laura; Daga-Ruiz, Domingo; Gordillo-Brenes, Antonio; Pacheco-Sánchez, María; Perez-Villares, José Miguel; Vilches-Arenas, Ángel; Egea-Guerrero, Juan José.
Afiliación
  • Palomo-López N; Department of Critical Care, Virgen del Rocío University Hospital, Av. Manuel Siurot s/n, 41013 Seville, Spain.
  • Rodríguez-Rodríguez A; Biomedical Institute of Seville, IBiS/CSIC/University of Seville, Calle Antonio Maura Montaner, 41013 Seville, Spain.
  • Martín-Villén L; Department of Critical Care, Virgen del Rocío University Hospital, Av. Manuel Siurot s/n, 41013 Seville, Spain.
  • Mendoza-Prieto M; Department of Critical Care, Virgen del Rocío University Hospital, Av. Manuel Siurot s/n, 41013 Seville, Spain.
  • Ruiz de Azúa-López Z; Department of Critical Care, Virgen del Rocío University Hospital, Av. Manuel Siurot s/n, 41013 Seville, Spain.
  • Sempere-Bordes L; Biomedical Institute of Seville, IBiS/CSIC/University of Seville, Calle Antonio Maura Montaner, 41013 Seville, Spain.
  • Boyero-Corral L; Biomedical Institute of Seville, IBiS/CSIC/University of Seville, Calle Antonio Maura Montaner, 41013 Seville, Spain.
  • Daga-Ruiz D; Department of Critical Care, Virgen de la Victoria University Hospital, Campus de Teatinos s/n, 29010 Málaga, Spain.
  • Gordillo-Brenes A; Department of Critical Care, Puerta del Mar University Hospital, Av. Ana de Viya, 21, 11009 Cádiz, Spain.
  • Pacheco-Sánchez M; Seville-Huelva Transplant Coordination Center, Av. Manuel Siurot s/n, 41013 Sevilla, Spain.
  • Perez-Villares JM; Department of Critical Care, Virgen de las Nieves University Hospital, Av. de las Fuerzas Armadas, 2, 18014 Granada, Spain.
  • Vilches-Arenas Á; Department of Preventive Medicine, University of Seville, Av. Sánchez Pizjuán s/n, 41009 Seville, Spain.
  • Egea-Guerrero JJ; Department of Critical Care, Virgen del Rocío University Hospital, Av. Manuel Siurot s/n, 41013 Seville, Spain.
Healthcare (Basel) ; 10(5)2022 Apr 20.
Article en En | MEDLINE | ID: mdl-35627899
The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medical history were collected. We also collected serial measurements of MDA, at 60 and 90 min after melatonin or placebo administration. A total of 53 donors were included (32 from DBD and 21 from DCD). In the DBD group, 17 donors received melatonin, and 15 placebo. Eight DCD donors were randomized to melatonin and 13 to placebo. Medical history and cause for LTE were similar between groups. Although MDA values did not differ in the DBD group, statistical differences were observed in DCD donors during the 0-60 min interval: -4.296 (-6.752; -2.336) in the melatonin group and -1.612 (-2.886; -0.7445) in controls. Given the antioxidant effect of melatonin, its use could reduce the production of oxidative stress in controlled DCD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Healthcare (Basel) Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials Idioma: En Revista: Healthcare (Basel) Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza