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Role of yUbp8 in Mitochondria and Hypoxia Entangles the Finding of Human Ortholog Usp22 in the Glioblastoma Pseudo-Palisade Microlayer.
De Luca, Veronica; Leo, Manuela; Cretella, Elisabetta; Montanari, Arianna; Saliola, Michele; Ciaffi, Gabriele; Vecchione, Andrea; Stoppacciaro, Antonella; Filetici, Patrizia.
Afiliación
  • De Luca V; Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Leo M; Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Cretella E; Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Montanari A; Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Saliola M; Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Ciaffi G; Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Vecchione A; Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Stoppacciaro A; Department of Clinical and Molecular Medicine, Sant' Andrea Hospital, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Filetici P; Institute of Molecular Biology and Pathology-CNR, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Cells ; 11(10)2022 05 19.
Article en En | MEDLINE | ID: mdl-35626719
KAT Gcn5 and DUB Ubp8 are required for respiration and mitochondria functions in budding yeast, and in this study we show that loss of respiratory activity is acquired over time. Interestingly, we show that absence of Ubp8 allows cells to grow in hypoxic conditions with altered mitophagy. Comparatively, the aggressive glioblastoma (GBM) multiforme tumor shows survival mechanisms able to overcome hypoxia in the brain. Starting from yeast and our findings on the role of Ubp8 in hypoxia, we extended our analysis to the human ortholog and signature cancer gene Usp22 in glioblastoma tumor specimens. Here we demonstrate that Usp22 is localized and overexpressed in the pseudo-palisade tissue around the necrotic area of the tumor. In addition, Usp22 colocalizes with the mitophagy marker Parkin, indicating a link with mitochondria function in GBM. Collectively, this evidence suggests that altered expression of Usp22 might provide a way for tumor cells to survive in hypoxic conditions, allowing the escape of cells from the necrotic area toward vascularized tissues. Collectively, our experimental data suggest a model for a possible mechanism of uncontrolled proliferation and invasion in glioblastoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioblastoma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cells Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioblastoma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cells Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza