Brinzolamide-loaded soft contact lens for ophthalmic delivery.
Ther Deliv
; 13(4): 233-247, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-35615865
Aim: In this study, brinzolamide (BRZ) was loaded in soft contact lens to improve drug delivery in glaucoma therapy. Materials & methods BRZ-loaded soft contact lens was prepared by the soaking method modifying pH, temperature and concentration of drug loading solution. Results: At pH 7.4, loading temperature and concentration of 32°C and 3 mg/ml, respectively, enhanced drug loading and release were observed. Diffusion is the main mechanism regulating drug release. BRZ loading brought no changes in the physical properties of soft contact lens, likewise, maintaining stability. Conclusion: The results demonstrated BRZ loading and delivery through soft contact lens which provides a potential alternative in glaucoma therapy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glaucoma
/
Lentes de Contacto Hidrofílicos
Límite:
Humans
Idioma:
En
Revista:
Ther Deliv
Año:
2022
Tipo del documento:
Article
País de afiliación:
Filipinas
Pais de publicación:
Reino Unido