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Non-structural proteins of bovine viral diarrhea virus.
Chi, Shanshan; Chen, Si; Jia, Weijuan; He, Yunjiang; Ren, Linzhu; Wang, Xueli.
Afiliación
  • Chi S; College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China.
  • Chen S; College of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, Changchun, 130062, China.
  • Jia W; College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China.
  • He Y; College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China.
  • Ren L; College of Animal Sciences, Key Lab for Zoonoses Research, Ministry of Education, Jilin University, Changchun, 130062, China. renlz@jlu.edu.cn.
  • Wang X; College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China. wangxl9577@aliyun.com.
Virus Genes ; 58(6): 491-500, 2022 Dec.
Article en En | MEDLINE | ID: mdl-35614328
Bovine viral diarrhea virus (BVDV) belongs to the family Flaviviridae genus pestivirus. The viral genome is a single-stranded, positive-sense RNA that encodes four structural proteins (i.e., C, Erns, E1, and E2) and eight non-structural proteins (NSPs) (i.e., Npro, p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). Cattle infected with BVDV exhibit a number of different clinical signs including diarrhea, abortion, and other reproductive disorders which have a serious impact on the cattle industry worldwide. Research on BVDV mainly focuses on its structural protein, however, progress in understanding the functions of the NSPs of BVDV has also been made in recent decades. The knowledge gained on the BVDV non-structural proteins is helpful to more fully understand the viral replication process and the molecular mechanism of viral persistent infection. This review focuses on the functions of BVDV NSPs and provides references for the identification of BVDV, the diagnosis and prevention of Bovine viral diarrhea mucosal disease (BVD-MD), and the development of vaccines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diarrea Mucosa Bovina Viral / Virus de la Diarrea Viral Bovina / Virus de la Diarrea Viral Bovina Tipo 1 Límite: Animals Idioma: En Revista: Virus Genes Asunto de la revista: BIOLOGIA MOLECULAR / VIROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diarrea Mucosa Bovina Viral / Virus de la Diarrea Viral Bovina / Virus de la Diarrea Viral Bovina Tipo 1 Límite: Animals Idioma: En Revista: Virus Genes Asunto de la revista: BIOLOGIA MOLECULAR / VIROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos