Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1<i>H</i>)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Guo, Jie; Xu, Airen; Cheng, Maojun; Wan, Yang; Wang, Rikang; Fang, Yuanying; Jin, Yi; Xie, Sai-Sai; Liu, Jing

Design, Synthesis and Biological Evaluation of New 3,4-Dihydro-2(1H)-Quinolinone-Dithiocarbamate Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Guo, Jie; Xu, Airen; Cheng, Maojun; Wan, Yang; Wang, Rikang; Fang, Yuanying; Jin, Yi; Xie, Sai-Sai; Liu, Jing.

Afiliación

Guo J; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Xu A; Clinical Pharmacology Research Center, The Second Hospital of Yinzhou, Ningbo, Zhejiang, People's Republic of China.
Cheng M; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Wan Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Wang R; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Fang Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Jin Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Xie SS; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.
Liu J; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People's Republic of China.

Drug Des Devel Ther ; 16: 1495-1514, 2022.

Article en En | MEDLINE | ID: mdl-35611357

Asunto(s)

Enfermedad de Alzheimer; Enfermedades Neurodegenerativas; Quinolonas; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/tratamiento farmacológico; Péptidos beta-Amiloides; Animales; Inhibidores de la Colinesterasa/farmacología; Diseño de Fármacos; Humanos; Hidroquinonas; Cinética; Ratones; Monoaminooxidasa/metabolismo; Inhibidores de la Monoaminooxidasa; Enfermedades Neurodegenerativas/tratamiento farmacológico; Quinolonas/farmacología; Quinolonas/uso terapéutico; Ratas; Relación Estructura-Actividad

Palabras clave

3,4-dihydro-2(1H)-quinolinone; Alzheimer's disease; cholinesterase; dithiocarbamate; monoamine oxidase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinolonas / Enfermedades Neurodegenerativas / Enfermedad de Alzheimer Límite: Animals / Humans Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article Pais de publicación: Nueva Zelanda

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