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miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing.
He, Wen-Zhen; Yang, Mi; Jiang, Yangzi; He, Chen; Sun, Yu-Chen; Liu, Ling; Huang, Mei; Jiao, Yu-Rui; Chen, Kai-Xuan; Hou, Jing; Huang, Min; Xu, Yi-Li; Feng, Xu; Liu, Ya; Guo, Qi; Peng, Hui; Huang, Yan; Su, Tian; Xiao, Ye; Li, Yusheng; Zeng, Chao; Lei, Guanghua; Luo, Xiang-Hang; Li, Chang-Jun.
Afiliación
  • He WZ; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Yang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Jiang Y; Institute for Tissue Engineering and Regenerative Medicine (iTERM), School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
  • He C; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Sun YC; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Liu L; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Huang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Jiao YR; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Chen KX; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Hou J; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Huang M; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Xu YL; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Feng X; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Liu Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Guo Q; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Peng H; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Huang Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Su T; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Xiao Y; Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Li Y; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Zeng C; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, 410008, Hunan, China.
  • Lei G; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Luo XH; Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
  • Li CJ; Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, 410008, Hunan, China.
Cell Death Dis ; 13(5): 494, 2022 05 25.
Article en En | MEDLINE | ID: mdl-35610206
A specific bone capillary subtype, namely type H vessels, with high expression of CD31 and endomucin, was shown to couple angiogenesis and osteogenesis recently. The number of type H vessels in bone tissue declines with age, and the underlying mechanism for this reduction is unclear. Here, we report that microRNA-188-3p (miR-188-3p) involves this process. miRNA-188-3p expression is upregulated in skeletal endothelium and negatively regulates the formation of type H vessels during ageing. Mice with depletion of miR-188 showed an alleviated age-related decline in type H vessels. In contrast, endothelial-specific overexpression of miR-188-3p reduced the number of type H vessels, leading to decreased bone mass and delayed bone regeneration. Mechanistically, we found that miR-188 inhibits type H vessel formation by directly targeting integrin ß3 in endothelial cells. Our findings indicate that miR-188-3p is a key regulator of type H vessel formation and may be a potential therapeutic target for preventing bone loss and accelerating bone regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / MicroARNs Límite: Animals Idioma: En Revista: Cell Death Dis Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / MicroARNs Límite: Animals Idioma: En Revista: Cell Death Dis Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido