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IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.
Kotas, Maya E; Moore, Camille M; Gurrola, Jose G; Pletcher, Steven D; Goldberg, Andrew N; Alvarez, Raquel; Yamato, Sheyla; Bratcher, Preston E; Shaughnessy, Ciaran A; Zeitlin, Pamela L; Zhang, Irene H; Li, Yingchun; Montgomery, Michael T; Lee, Keehoon; Cope, Emily K; Locksley, Richard M; Seibold, Max A; Gordon, Erin D.
Afiliación
  • Kotas ME; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Moore CM; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
  • Gurrola JG; Department of Biostatistics and Informatics, University of Colorado, Aurora, Colorado, USA.
  • Pletcher SD; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Goldberg AN; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Alvarez R; Surgical Service, ENT Section, San Francisco VA Medical Center, San Francisco, California, USA.
  • Yamato S; Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, California, USA.
  • Bratcher PE; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Shaughnessy CA; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Zeitlin PL; Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
  • Zhang IH; Department of Pediatrics, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA.
  • Li Y; Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
  • Montgomery MT; Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
  • Lee K; Department of Pediatrics, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA.
  • Cope EK; Center for Applied Microbiome Sciences, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
  • Locksley RM; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
  • Seibold MA; Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.
  • Gordon ED; Center for Applied Microbiome Sciences, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA.
JCI Insight ; 7(13)2022 07 08.
Article en En | MEDLINE | ID: mdl-35608904
Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory and ciliated cells). The role of rare cells in airway T2 inflammation is less clear, though tuft cells have been shown to be critical in the initiation of T2 immunity in the intestine. Using bulk and single-cell RNA sequencing of airway epithelium and mouse modeling, we found that IL-13 expanded and programmed airway tuft cells toward eicosanoid metabolism and that tuft cell deficiency led to a reduction in airway prostaglandin E2 (PGE2) concentration. Allergic airway epithelia bore a signature of PGE2 activation, and PGE2 activation led to cystic fibrosis transmembrane receptor-dependent ion and fluid secretion and accelerated mucociliary transport. These data reveal a role for tuft cells in regulating epithelial mucociliary function in the allergic airway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística Límite: Animals Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Fibrosis Quística Límite: Animals Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos