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Biocompatible fluorescent silk fibroin bioink for digital light processing 3D printing.
Lee, Young Jin; Lee, Joong Seob; Ajiteru, Olatunji; Lee, Ok Joo; Lee, Ji Seung; Lee, Hanna; Kim, Seong Wan; Park, Jong Woo; Kim, Kee Young; Choi, Kyu Young; Hong, Heesun; Sultan, Tipu; Kim, Soon Hee; Park, Chan Hum.
Afiliación
  • Lee YJ; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Lee JS; Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of Korea.
  • Ajiteru O; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Lee OJ; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Lee JS; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Lee H; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Kim SW; Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, Jeollabuk-do 55365, Republic of Korea.
  • Park JW; Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, Jeollabuk-do 55365, Republic of Korea.
  • Kim KY; Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, Jeollabuk-do 55365, Republic of Korea.
  • Choi KY; Depratment of Otorhinolaryngology-Head and Neck Surgery, Kangnam Sacred Heart Hospital, Seoul 07441, Republic of Korea.
  • Hong H; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Sultan T; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Kim SH; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea.
  • Park CH; Nano-Bio Regenerative Medical Institute (NBRM), Hallym University, Chuncheon 24252, Republic of Korea; Depratment of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Chuncheon 24253, Republic of Korea. Electronic address: hlpch@paran.com.
Int J Biol Macromol ; 213: 317-327, 2022 Jul 31.
Article en En | MEDLINE | ID: mdl-35605719
Chemically modified silk fibroin (SF) bioink has been used for three-dimensional (3D) bioprinting in tissue engineering because of its biocompatibility and printability. Also, fluorescent silk fibroin (FSF) from transgenic silkworms has been recently applied in biomedicine because of its fluorescence property. However, the fabrication of fluorescent hydrogel from FSF has not been elucidated. In this study, we showed the fabrication of a digital light processing (DLP) printable bioink from a chemically modified FSF. This bioink was fabricated by covalent conjugation of FSF and glycidyl methacrylate (GMA) and can be printed into various structures, such as the brain, ear, hand, lung, and internal organs. The physical properties of glycidyl methacrylated fluorescent silk fibroin (FSGMA) hydrogel was like the glycidyl methacrylated non-fluorescent silk fibroin (SGMA) hydrogel. The FSGMA hydrogel significantly retains its fluorescence property and has excellent biocompatibility. All these properties make FSGMA hydrogel a potent tool in encapsulated cell tracking and observing the scaffolds' degradation in vivo. This study suggested that our 3D DLP printable FSF bioink could play a promising role in the biomedical field.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibroínas / Bioimpresión Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibroínas / Bioimpresión Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos