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Risk Factors for Coronary Artery Lesionsin Kawasaki Disease Independent of Antibiotic Use in Chinese Children.
Lao, Sixian; Zhou, Tao; Kuo, Ho-Chang; Zhong, Guoping; Zeng, Weiwei.
Afiliación
  • Lao S; Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
  • Zhou T; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangzhou, China.
  • Kuo HC; Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen, China.
  • Zhong G; Kawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
  • Zeng W; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Front Public Health ; 10: 817613, 2022.
Article en En | MEDLINE | ID: mdl-35602151
Objectives: To study the impact of antibiotics used in Kawasaki disease (KD) with coronary artery lesions (CAL) and identify independent risk factors. Methodology: This study reviewed the records of 287 KD patients between the years 2016 and 2020. Patients were grouped by their outcome, the CAL group, and a no-coronary artery lesions (NCAL) group, and stratified by the use of antibiotics. We collected clinical and laboratory data before the intravenous immunoglobulin (IVIG) treatment. Results: The two groups of KD patients with and without CAL were compared. The results showed that there are significant differences between groups which were erythrocyte count (p = 0.045) and hemoglobin (p = 0.005), red blood cell-specific volume (p = 0.001), immature granular cells percentage (p = 0.006), total protein (p = 0.045), albumin (p = 0.041), alkaline phosphatase (p = 0.023), and chlorine (p = 0.006). After multivariate logistic regression, neutrophil granulocyte percentage (odds ratio [OR] = 1.200, 95% confidence interval [CI]: 1.008-1.428, p = 0.040), lymphocyte percentage (p = 0.028, OR = 1.243, 95% CI: 1.024-1.508, p = 0.028) and total protein (OR = 4.414, 95% CI: 1.092-17.846, p = 0.037) were found to be independent risk factors for CAL. After analyzing the cases with a history of antibiotic use, multivariate analysis showed no indicators were considered independent risk factors for CAL. Conclusion: Neutrophil granulocyte percentage, Lymphocyte percentage and total protein were independent risks for CAL in KD without antibiotics use history. The use of antibiotics affected physiological indicators of KD patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Síndrome Mucocutáneo Linfonodular Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans País/Región como asunto: Asia Idioma: En Revista: Front Public Health Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Síndrome Mucocutáneo Linfonodular Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Humans País/Región como asunto: Asia Idioma: En Revista: Front Public Health Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza