Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X.

Zhang, Zhi-Li; Chen, Changming; Qu, Si-Ying; Ding, Qiulan; Xu, Qin

Zhang, Zhi-Li; Chen, Changming; Qu, Si-Ying; Ding, Qiulan; Xu, Qin.

Afiliación

Zhang ZL; State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Chen C; Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qu SY; State Key Laboratory of Microbial Metabolism & Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Ding Q; Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu Q; Collaborative Innovation Center of Hematology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Front Mol Biosci ; 9: 877170, 2022.

Article en En | MEDLINE | ID: mdl-35601826

Palabras clave

coagulation factors; molecular dynamics simulations; molecular flexibility; rivaroxaban; structure-based drug design

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Mol Biosci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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