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Hydrogels for Tissue Engineering: Addressing Key Design Needs Toward Clinical Translation.
Xu, Fei; Dawson, Chloe; Lamb, Makenzie; Mueller, Eva; Stefanek, Evan; Akbari, Mohsen; Hoare, Todd.
Afiliación
  • Xu F; Department of Chemical Engineering, McMaster University, Hamilton, ON, Canada.
  • Dawson C; Department of Chemical Engineering, McMaster University, Hamilton, ON, Canada.
  • Lamb M; Department of Chemical Engineering, McMaster University, Hamilton, ON, Canada.
  • Mueller E; Department of Chemical Engineering, McMaster University, Hamilton, ON, Canada.
  • Stefanek E; Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada.
  • Akbari M; Center for Advanced Materials and Related Technologies, University of Victoria, Victoria, BC, Canada.
  • Hoare T; Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada.
Front Bioeng Biotechnol ; 10: 849831, 2022.
Article en En | MEDLINE | ID: mdl-35600900
While the soft mechanics and tunable cell interactions facilitated by hydrogels have attracted significant interest in the development of functional hydrogel-based tissue engineering scaffolds, translating the many positive results observed in the lab into the clinic remains a slow process. In this review, we address the key design criteria in terms of the materials, crosslinkers, and fabrication techniques useful for fabricating translationally-relevant tissue engineering hydrogels, with particular attention to three emerging fabrication techniques that enable simultaneous scaffold fabrication and cell loading: 3D printing, in situ tissue engineering, and cell electrospinning. In particular, we emphasize strategies for manufacturing tissue engineering hydrogels in which both macroporous scaffold fabrication and cell loading can be conducted in a single manufacturing step - electrospinning, 3D printing, and in situ tissue engineering. We suggest that combining such integrated fabrication approaches with the lessons learned from previously successful translational experiences with other hydrogels represents a promising strategy to accelerate the implementation of hydrogels for tissue engineering in the clinic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Bioeng Biotechnol Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza