Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models.

Sardoiwala, Mohammed Nadim; Mohanbhai, Soni Jignesh; Kushwaha, Avinash Chandra; Dev, Atul; Biswal, Liku; Sharma, Shyam Sunder; Choudhury, Subhasree Roy; Karmakar, Surajit

Sardoiwala, Mohammed Nadim; Mohanbhai, Soni Jignesh; Kushwaha, Avinash Chandra; Dev, Atul; Biswal, Liku; Sharma, Shyam Sunder; Choudhury, Subhasree Roy; Karmakar, Surajit.

Afiliación

Sardoiwala MN; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India.
Mohanbhai SJ; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India.
Kushwaha AC; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India.
Dev A; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India.
Biswal L; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India.
Sharma SS; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, SAS, Nagar, Punjab, 160062, India.
Choudhury SR; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India. Electronic address: subhasreerc@inst.ac.in.
Karmakar S; Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge City, SAS Nagar, Punjab 140306, India. Electronic address: surajit@inst.ac.in.

Life Sci ; 302: 120655, 2022 Aug 01.

Article en En | MEDLINE | ID: mdl-35598656

Asunto(s)

Colitis; Enfermedades Inflamatorias del Intestino; Melatonina; Animales; Ratones; Colitis/inducido químicamente; Colitis/tratamiento farmacológico; Colitis/genética; Sulfato de Dextran/toxicidad; Dextranos/metabolismo; Modelos Animales de Enfermedad; Proteína Potenciadora del Homólogo Zeste 2/metabolismo; Epigénesis Genética; Enfermedades Inflamatorias del Intestino/patología; Melatonina/farmacología; Melatonina/uso terapéutico; Óxido Nítrico Sintasa de Tipo II/metabolismo

Palabras clave

Dextran sodium sulphate; EZH2; Epigenetic; Melatonin; Ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis / Melatonina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos

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