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Long-term exercise at different intensities can reduce the inflammatory response in the brains of methamphetamine-treated mice.
Li, Yue; Re, Guo-Fen; Zhao, Yu; Wu, Xiao-Cong; Zhou, Rui-Yi; Kuang, Yi-Qun; Wang, Kun-Hua.
Afiliación
  • Li Y; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Re GF; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Zhao Y; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Wu XC; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Zhou RY; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
  • Kuang YQ; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. Electronic address: yq610433@hotmail.com.
  • Wang KH; NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, 650032, China; School of Medicine,Yunnan University, Kunming, 650032, China. Electronic address: khwang@ynu.edu.cn.
Biochem Biophys Res Commun ; 613: 201-206, 2022 07 12.
Article en En | MEDLINE | ID: mdl-35598376
Methamphetamine (METH) is a highly addictive psychoactive drug that is used worldwide. Various approaches have been used to address METH dependence, but many of them have little effect. Previous studies have shown that exercise on a treadmill could reduce METH dependence in mice, but the intensity and duration of exercise that was needed to be effective was unknown. This study investigated the effects of low- and medium-intensity treadmill exercise on methamphetamine reward in male mice via conditioned place preference (CPP) training, and the levels of the inflammatory factors IL-1ß, IL-6 and TNF-α in three brain regions (cerebral cortex, hippocampus and striatum) were determined. The results showed that long-term medium-intensity exercise reduced the effects of methamphetamine on inflammation markers in the brain and CPP scores. In addition, long-term medium-intensity exercise decreased IL-1ß concentrations in the cerebral cortex and hippocampus, reduced IL-6 concentrations in the striatum, and reduced TNF-α concentrations in the cerebral cortex, hippocampus, and striatum in methamphetamine-treated mice; low-intensity exercise was less effective. The results indicated that long-term medium-intensity exercise could reduce concentrations of methamphetamine-induced encephalitis factors in male mice, while low-intensity exercise was less effective in alleviating dependence and inflammatory responses. It is suggested that exercise intensity is an important factor affecting the dependence level and inflammatory responses in the brain in mice administered methamphetamine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulantes del Sistema Nervioso Central / Metanfetamina Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulantes del Sistema Nervioso Central / Metanfetamina Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos