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Neural Activation in the Ventromedial Prefrontal Cortex Precedes Conscious Experience of Being in or out of a Transient Hallucinatory State.
Hugdahl, Kenneth; Craven, Alexander R; Johnsen, Erik; Ersland, Lars; Stoyanov, Drozdstoy; Kandilarova, Sevdalina; Brunvoll Sandøy, Lydia; Kroken, Rune A; Løberg, Else-Marie; Sommer, Iris E C.
Afiliación
  • Hugdahl K; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
  • Craven AR; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
  • Johnsen E; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
  • Ersland L; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
  • Stoyanov D; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.
  • Kandilarova S; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
  • Brunvoll Sandøy L; NORMENT Center for the Study of Mental Disorders, Haukeland University Hospital, Bergen, Norway.
  • Kroken RA; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  • Løberg EM; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
  • Sommer IEC; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.
Schizophr Bull ; 49(Suppl_1): S58-S67, 2023 02 24.
Article en En | MEDLINE | ID: mdl-35596662
BACKGROUND AND HYPOTHESES: Auditory verbal hallucinations (AVHs) is not only a common symptom in schizophrenia but also observed in individuals in the general population. Despite extensive research, AVHs are poorly understood, especially their underlying neuronal architecture. Neuroimaging methods have been used to identify brain areas and networks that are activated during hallucinations. A characteristic feature of AVHs is, however, that they fluctuate over time, with varying frequencies of starts and stops. An unanswered question is, therefore, what neuronal events co-occur with the initiation and inhibition of an AVH episode. STUDY DESIGN: We investigated brain activation with fMRI in 66 individuals who experienced multiple AVH-episodes while in the scanner. We extracted time-series fMRI-data and monitored changes second-by-second from 10 s before to 15 s after participants indicated the start and stop of an episode, respectively, by pressing a hand-held response-button. STUDY RESULTS: We found a region in the ventromedial prefrontal cortex (VMPFC) which showed a significant increase in activation initiated a few seconds before participants indicated the start of an episode, and a corresponding decrease in activation initiated a few seconds before the end of an episode. CONCLUSIONS: The consistent increase and decrease in activation in this area in advance of the consciously experienced presence or absence of the "voice" imply that this region may act as a switch in turning episodes on and off. The activation is unlikely to be confounded by motor responses. The findings could have clinical implications for brain stimulation treatments, like transcranial magnetic stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Alucinaciones Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Schizophr Bull Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Alucinaciones Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Schizophr Bull Año: 2023 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Estados Unidos