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Macrophage orchestration of epithelial and stromal cell homeostasis in the intestine.
Cao, Qian; Mertens, Randall Tyler; Sivanathan, Kisha Nandini; Cai, Xuechun; Xiao, Peng.
Afiliación
  • Cao Q; Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Mertens RT; Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Sivanathan KN; Department of Immunology, Harvard Medical School, Boston, Massachusetts, USA.
  • Cai X; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Xiao P; Department of Immunology, Harvard Medical School, Boston, Massachusetts, USA.
J Leukoc Biol ; 112(2): 313-331, 2022 08.
Article en En | MEDLINE | ID: mdl-35593111
The intestinal tract is a complex ecosystem where numerous cell types of epithelial, immune, neuronal, and endothelial origin coexist in an intertwined, highly organized manner. The functional equilibrium of the intestine relies heavily on the proper crosstalk and cooperation among each cell population. Furthermore, macrophages are versatile, innate immune cells that participate widely in the modulation of inflammation and tissue remodeling. Emerging evidence suggest that macrophages are central in orchestrating tissue homeostasis. Herein, we describe how macrophages interact with epithelial cells, neurons, and other types of mesenchymal cells under the context of intestinal inflammation, followed by the therapeutic implications of cellular crosstalk pertaining to the treatment of inflammatory bowel disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Mucosa Intestinal Límite: Humans Idioma: En Revista: J Leukoc Biol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Mucosa Intestinal Límite: Humans Idioma: En Revista: J Leukoc Biol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido