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Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis.
Carter, Marissa J; Frykberg, Robert G; Oropallo, Alisha; Sen, Chandan K; Armstrong, David G; Nair, Harikrishna K R; Serena, Thomas E.
Afiliación
  • Carter MJ; Strategic Solutions, Inc., Bozeman, Montana, USA.
  • Frykberg RG; Diabetic Foot Consultants, Midwestern University, Glendale, Arizona, USA.
  • Oropallo A; Department of Vascular Surgery, Donald and Barbara Zucker School of Medicine, Hofstra/Northwell Health, Hempstead, New York, USA.
  • Sen CK; Indiana Center for Regenerative Medicine and Engineering, School of Medicine, Indiana University, Indianapolis, Indiana, USA.
  • Armstrong DG; Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
  • Nair HKR; Wounds Malaysia, Wound Care Unit, Department of Internal Medicine, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.
  • Serena TE; SerenaGroup Research Foundation, Cambridge, Massachusetts, USA.
Adv Wound Care (New Rochelle) ; 12(4): 177-186, 2023 04.
Article en En | MEDLINE | ID: mdl-35593010
Objective: To conduct a systematic review and meta-analysis of recently published randomized controlled trials (RCTs) that employed the use of topical oxygen therapy (TOT) as an adjunct therapy in the treatment of Wagner 1 and 2 diabetic foot ulcers. Approach: Following a literature search of eligible studies from 2010 onward, four RCTs were included. Studies were analyzed for patient and wound characteristics, outcomes, risk of bias, and quality of the evidence assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. A random-effects meta-analysis for complete wound healing was carried out due to statistical heterogeneity of included studies. Results: Risk of bias judgment (RoB2 analysis) resulted in one low-risk trial and three trials with some risk. One study was determined to be the origin of the statistical heterogeneity. Pooled results showed statistical significance with a risk ratio (RR) of 1.59 (95% confidence interval [CI]: 1.07-2.37; p = 0.021). Sensitivity analysis, based on imputed values for missing outcomes, demonstrated that both the RR and 95% CIs changed little. The GRADE ratings for each domain were as follows: (a) risk of bias: moderate (3); (b) imprecision: moderate (2), high (1); (c) inconsistency: low (2), high (1); (d) indirectness: moderate (2), high (1); and (e) publication bias: moderate (1), high (2). Overall, the evidence was moderate. Innovation: Our study shows that TOT is a viable diabetic foot ulcer therapy. Conclusions: These data support the use of TOT for the treatment of chronic Wagner 1 or 2 diabetic foot ulcers in the absence of infection and ischemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera del Pie / Pie Diabético / Diabetes Mellitus Tipo de estudio: Clinical_trials / Guideline / Systematic_reviews Límite: Humans Idioma: En Revista: Adv Wound Care (New Rochelle) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Úlcera del Pie / Pie Diabético / Diabetes Mellitus Tipo de estudio: Clinical_trials / Guideline / Systematic_reviews Límite: Humans Idioma: En Revista: Adv Wound Care (New Rochelle) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos