Your browser doesn't support javascript.
loading
A Systematic Review and Network Meta-Analysis about the Efficacy and Safety of Tripterygium wilfordii Hook F in Rheumatoid Arthritis.
Wang, Hai-Long; Zhao, Qi; Li, Wei; Zhu, Hua-Chao; Lv, Liu; Zhu, Zhen-Hong; Wang, Xi-Xi; Yang, Zheng-Zheng; Ma, Yu-Cao; Liu, Ming-Xuan; Wang, Yi-Wen; Lai, Hezheng; Liu, Chun-Ping; Yang, Yu-Zheng.
Afiliación
  • Wang HL; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Zhao Q; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Li W; Chinese Medicine Centre, Western Sydney University, Penrith, NSW 2751, Australia.
  • Zhu HC; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Lv L; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Zhu ZH; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Wang XX; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Yang ZZ; Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
  • Ma YC; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
  • Liu MX; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
  • Wang YW; Beijing University of Chinese Medicine, Beijing 100700, China.
  • Lai H; Beijing University of Chinese Medicine, Beijing 100700, China.
  • Liu CP; Chinese Medicine Centre, Western Sydney University, Penrith, NSW 2751, Australia.
  • Yang YZ; Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
Evid Based Complement Alternat Med ; 2022: 3181427, 2022.
Article en En | MEDLINE | ID: mdl-35591865
Objective: This study aims to evaluate the efficacy of various conventional synthetic DMARDs, including Tripterygium wilfordii Hook F (TwHF) for treating rheumatoid arthritis (RA) by network meta-analysis. Methods: We retrieved the related literature from online databases and supplemented it by using a manual retrieval method. Data was extracted from the literature and analyzed with STATA software. Results: A total of 21 trials (5,039 participants) were identified. Assessment of ACR20 response found that TwHF combined with methotrexate (MTX) had the greatest probability for being the best treatment option among the treatments involved, while TwHF used singly was second only to TwHF combined with MTX. Assessment of ACR50 response found that TwHF combined with MTX ranked second in all treatment options after cyclosporine A (CsA) combined with leflunomide (LEF) and TwHF alone, followed by TwHF combined with MTX. Assessment of ACR70 response found that CsA combined with LEF ranked first, TwHF combined with LEF ranked second, TwHF combined with MTX ranked third, and TwHF used singly ranked fourth. In the safety analysis, TwHF had the least probability of adverse event occurrence, followed by TwHF combined with MTX, which ranked first and second, respectively. Conclusion: Compared with the current csDMARDs for treating RA, the efficacy of TwHF was clear, and TwHF combined with MTX performed well under various endpoints. In the future, large, rigorous, and high-quality RCTs are still needed to confirm the benefits of TwHF therapy on RA.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Systematic_reviews Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline / Systematic_reviews Idioma: En Revista: Evid Based Complement Alternat Med Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos