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Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys.
Harper, Tod; Sharma, Amy; Kaliyaperumal, Sarav; Fajardo, Flordeliza; Hsu, Katie; Liu, Lily; Davies, Rhian; Wei, Yu-Ling; Zhan, Jinghui; Estrada, Juan; Kvesic, Majk; Nahrwold, Lisa; Deisting, Wibke; Panzer, Marc; Cooke, Keegan; Lebrec, Hervé; Nolan-Stevaux, Olivier.
Afiliación
  • Harper T; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Sharma A; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Kaliyaperumal S; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Fajardo F; Oncology Therapeutic Area, Amgen, South San Francisco, California 94080, USA.
  • Hsu K; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Liu L; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Davies R; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Wei YL; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Zhan J; Oncology Therapeutic Area, Amgen, Thousand Oaks, California 91320, USA.
  • Estrada J; Oncology Therapeutic Area, Amgen, Thousand Oaks, California 91320, USA.
  • Kvesic M; Therapeutic Discovery, Amgen Research (Munich) GmbH, 81477 Munich, Germany.
  • Nahrwold L; Therapeutic Discovery, Amgen Research (Munich) GmbH, 81477 Munich, Germany.
  • Deisting W; Therapeutic Discovery, Amgen Research (Munich) GmbH, 81477 Munich, Germany.
  • Panzer M; Therapeutic Discovery, Amgen Research (Munich) GmbH, 81477 Munich, Germany.
  • Cooke K; Oncology Therapeutic Area, Amgen, Thousand Oaks, California 91320, USA.
  • Lebrec H; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, California, 94080, USA.
  • Nolan-Stevaux O; Oncology Therapeutic Area, Amgen, South San Francisco, California 94080, USA.
Toxicol Sci ; 189(1): 32-50, 2022 08 25.
Article en En | MEDLINE | ID: mdl-35583313
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos