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Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination.
Matsui, Yusuke; Li, Lin; Prahl, Mary; Cassidy, Arianna G; Ozarslan, Nida; Golan, Yarden; Gonzalez, Veronica J; Lin, Christine Y; Jigmeddagva, Unurzul; Chidboy, Megan A; Montano, Mauricio; Taha, Taha Y; Khalid, Mir M; Sreekumar, Bharath; Hayashi, Jennifer M; Chen, Pei-Yi; Kumar, G Renuka; Warrier, Lakshmi; Wu, Alan Hb; Song, Dongli; Jegatheesan, Priya; Rai, Daljeet S; Govindaswami, Balaji; Needens, Jordan; Rincon, Monica; Myatt, Leslie; Asiodu, Ifeyinwa V; Flaherman, Valerie J; Afshar, Yalda; Jacoby, Vanessa L; Murtha, Amy P; Robinson, Joshua F; Ott, Melanie; Greene, Warner C; Gaw, Stephanie L.
Afiliación
  • Matsui Y; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Li L; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, California, USA.
  • Prahl M; Division of Maternal-Fetal Medicine and.
  • Cassidy AG; Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, California, USA.
  • Ozarslan N; Department of Pediatrics.
  • Golan Y; Division of Pediatric Infectious Diseases and Global Health.
  • Gonzalez VJ; Division of Maternal-Fetal Medicine and.
  • Lin CY; Division of Maternal-Fetal Medicine and.
  • Jigmeddagva U; Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, California, USA.
  • Chidboy MA; Department of Bioengineering and Therapeutic Sciences.
  • Montano M; Division of Maternal-Fetal Medicine and.
  • Taha TY; Division of Maternal-Fetal Medicine and.
  • Khalid MM; Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, California, USA.
  • Sreekumar B; Division of Maternal-Fetal Medicine and.
  • Hayashi JM; Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, UCSF, San Francisco, California, USA.
  • Chen PY; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Kumar GR; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, California, USA.
  • Warrier L; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Wu AH; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Song D; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Jegatheesan P; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Rai DS; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Govindaswami B; Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, USA.
  • Needens J; Department of Family Health Care Nursing, and.
  • Rincon M; Department of Laboratory Medicine, UCSF, San Francisco, California, USA.
  • Myatt L; Department of Pediatrics, Division of Neonatology, Santa Clara Valley Medical Center, San Jose, California, USA.
  • Asiodu IV; Department of Pediatrics, Division of Neonatology, Santa Clara Valley Medical Center, San Jose, California, USA.
  • Flaherman VJ; Stanford-O'Connor Family Medicine Residency Program, Division of Family Medicine, Stanford University, Palo Alto, California, USA.
  • Afshar Y; Department of Pediatrics, Division of Neonatology, and.
  • Jacoby VL; Department of Obstetrics and Gynecology, Marshall University Joan C. Edwards School of Medicine, Huntington, West Virginia, USA.
  • Murtha AP; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
  • Robinson JF; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon, USA.
  • Ott M; Department of Family Health Care Nursing, and.
  • Greene WC; Department of Pediatrics.
  • Gaw SL; Department of Obstetrics and Gynecology, UCLA, Los Angeles, California, USA.
JCI Insight ; 7(12)2022 06 22.
Article en En | MEDLINE | ID: mdl-35579965
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure. Neutralization activity against the 5 SARS-CoV-2 spike sequences was measured by a SARS-CoV-2-pseudotyped spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared with WT spike protein, these nAbs were less effective against the Delta and Mu spike variants. Vaccination during the third trimester induced higher cord-nAb levels at delivery than did infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared with infection during the first trimester. The transfer ratio (cord nAb level divided by maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicits effective nAbs with differing neutralization kinetics that are influenced by gestational time of exposure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Female / Humans Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Female / Humans Idioma: En Revista: JCI Insight Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos