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Pancreas Transplantation for Type 2 Diabetes: A Systematic Review, Critical Gaps in the Literature, and a Path Forward.
Amara, Dominic; Hansen, Keith S; Kupiec-Weglinski, Sophie A; Braun, Hillary J; Hirose, Ryutaro; Hilton, Joan F; Rickels, Michael R; Odorico, Jon S; Stock, Peter G.
Afiliación
  • Amara D; School of Medicine, University of California, San Francisco, San Francisco, CA.
  • Hansen KS; Department of Surgery, University of California, San Francisco, San Francisco, CA.
  • Kupiec-Weglinski SA; School of Medicine, University of California, San Francisco, San Francisco, CA.
  • Braun HJ; Department of Surgery, University of California, San Francisco, San Francisco, CA.
  • Hirose R; Department of Surgery, University of California, San Francisco, San Francisco, CA.
  • Hilton JF; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
  • Rickels MR; Department of Medicine, University of Pennsylvania, Philadelphia, PA.
  • Odorico JS; Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
  • Stock PG; Department of Surgery, University of California, San Francisco, San Francisco, CA.
Transplantation ; 106(10): 1916-1934, 2022 10 01.
Article en En | MEDLINE | ID: mdl-35576270
Pancreas transplantation in patients with type 2 diabetes (T2D) remains relatively uncommon compared with pancreas transplantation in patients with type 1 diabetes (T1D); however, several studies have suggested similar outcomes between T2D and T1D, and the practice has become increasingly common. Despite this growing interest in pancreas transplantation in T2D, no study has systematically summarized the data to date. We systematically reviewed the literature on pancreas transplantation in T2D patients including patient and graft survival, glycemic control outcomes, and comparisons with outcomes in T2D kidney transplant alone and T1D pancreas transplant recipients. We searched biomedical databases from January 1, 2000, to January 14, 2021, and screened 3314 records, of which 22 full texts and 17 published abstracts met inclusion criteria. Full-text studies were predominantly single center (73%), whereas the remaining most often studied the Organ Procurement and Transplantation Network database. Methodological quality was mixed with frequent concern for selection bias and concern for inconsistent definitions of both T2D and pancreas graft survival across studies. Overall, studies generally reported favorable patient survival, graft survival, and glycemic control outcomes for pancreas transplantation in T2D and expressed a need to better characterize the T2D patients who would benefit most from pancreas transplantation. We suggest guidance for future studies, with the aim of supporting the safe and evidence-based treatment of end-stage T2D and judicious use of scarce resources.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Trasplante de Páncreas / Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Guideline / Systematic_reviews Límite: Humans Idioma: En Revista: Transplantation Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Trasplante de Páncreas / Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 Tipo de estudio: Diagnostic_studies / Guideline / Systematic_reviews Límite: Humans Idioma: En Revista: Transplantation Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos