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The latest role of nerve-specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons.
Chen, Xing-Dong; Liu, Hui-Lin; Li, Sen; Hu, Kai-Bin; Wu, Qing-Yun; Liao, Ping; Wang, Hai-Yan; Long, Zai-Yun; Lu, Xiu-Min; Wang, Yong-Tang.
Afiliación
  • Chen XD; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
  • Liu HL; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China.
  • Li S; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
  • Hu KB; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China.
  • Wu QY; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
  • Liao P; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
  • Wang HY; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
  • Long ZY; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China.
  • Lu XM; State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China.
  • Wang YT; College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Wiley Interdiscip Rev RNA ; 14(2): e1740, 2023 03.
Article en En | MEDLINE | ID: mdl-35574699
Central nervous system injury diseases can cause the loss of many neurons, and it is difficult to regenerate. The field of regenerative medicine believes that supplementing the missing neurons may be an ideal method for nerve injury repair. Recent studies have found that down-regulation of polypyrimidine tract binding protein 1 (PTBP1) expression can make glial cells transdifferentiate into different types of neurons, which is expected to be an alternative therapy to restore neuronal function. This article summarized the research progress on the structure and biological function of the PTBP family, the mutual regulation of PTBP1 and PTBP2, their role in neurogenesis, and the latest research progress in targeting PTBP1 to mediate the transdifferentiation of glial cells into neurons, which may provide some new strategies and new ideas for the future treatment of central nervous system injury and neurodegenerative diseases. This article is categorized under: RNA Processing > Splicing Regulation/Alternative Splicing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína de Unión al Tracto de Polipirimidina / Transdiferenciación Celular Idioma: En Revista: Wiley Interdiscip Rev RNA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína de Unión al Tracto de Polipirimidina / Transdiferenciación Celular Idioma: En Revista: Wiley Interdiscip Rev RNA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos