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Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria.
Drummond, Rebecca A; Desai, Jigar V; Ricotta, Emily E; Swamydas, Muthulekha; Deming, Clay; Conlan, Sean; Quinones, Mariam; Matei-Rascu, Veronika; Sherif, Lozan; Lecky, David; Lee, Chyi-Chia R; Green, Nathaniel M; Collins, Nicholas; Zelazny, Adrian M; Prevots, D Rebecca; Bending, David; Withers, David; Belkaid, Yasmine; Segre, Julia A; Lionakis, Michail S.
Afiliación
  • Drummond RA; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA; Institute of Immunology & Immunotherapy, Institute of Microbiology & Infectio
  • Desai JV; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Ricotta EE; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Swamydas M; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Deming C; Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Conlan S; Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Quinones M; Bioinformatics and Computational Bioscience Branch, NIAID, NIH, Bethesda, MD 20892, USA.
  • Matei-Rascu V; Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham, B15 2TT, UK.
  • Sherif L; Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham, B15 2TT, UK.
  • Lecky D; Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham, B15 2TT, UK.
  • Lee CR; Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Green NM; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Collins N; Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, NIAID, NIH, Bethesda, MD 20892, USA.
  • Zelazny AM; Department of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD 20892, USA.
  • Prevots DR; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  • Bending D; Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham, B15 2TT, UK.
  • Withers D; Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham, B15 2TT, UK.
  • Belkaid Y; Metaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, NIAID, NIH, Bethesda, MD 20892, USA; NIAID Microbiome Program, NIAID, NIH, Bethesda, MD 20892, USA.
  • Segre JA; Microbial Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
  • Lionakis MS; Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. Electronic address: lionakism@mail.nih.gov.
Cell Host Microbe ; 30(7): 1020-1033.e6, 2022 07 13.
Article en En | MEDLINE | ID: mdl-35568028
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis Invasiva / Coinfección / Antibacterianos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candidiasis Invasiva / Coinfección / Antibacterianos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos