Your browser doesn't support javascript.
loading
Structural language impairment in Autism Spectrum Disorder versus Loss of Autism Diagnosis: Behavioral and neural characteristics.
Larson, Caroline; Rivera-Figueroa, Karla; Thomas, Hannah R; Fein, Deborah; Stevens, Michael C; Eigsti, Inge-Marie.
Afiliación
  • Larson C; Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA; CT Institute for the Brain and Cognitive Sciences, Storrs, CT, USA. Electronic address: caroline.larson@uconn.edu.
  • Rivera-Figueroa K; Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
  • Thomas HR; Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
  • Fein D; Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA; Department of Pediatrics, University of Connecticut, Farmington, CT, USA.
  • Stevens MC; Olin Neuropsychiatry Research Center at the Institute of Living, Hartford, CT, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
  • Eigsti IM; Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA; CT Institute for the Brain and Cognitive Sciences, Storrs, CT, USA.
Neuroimage Clin ; 34: 103043, 2022.
Article en En | MEDLINE | ID: mdl-35567947
This study probed for structural language impairment using behavioral and functional neuroimaging methods in individuals with Autism Spectrum Disorder (ASD) and those diagnosed with ASD in childhood who no longer meet criteria for ASD, referred to as Loss of Autism Diagnosis (LAD1). Participants were drawn from Fein et al. (2013): ASD (n = 35), LAD (n = 31), and Neurotypical (NT; n = 34). Criteria for structural language impairment were: Scores ≤ 82 on Clinical Evaluation of Language Fundamentals-4 (CELF) Core Language, an omnibus measure of language; and scores ≤ 7 on CELF Recalling Sentences, a clinical marker of structural language impairment. Task-based fMRI examined lateralization of significantly activated language-related brain regions in groups with structural language impairment (LI2) versus normal-range language (LN3), collapsed across ASD, LAD1, and NT status. Results showed no ASD versus LAD group differences in the proportion of participants with structural language impairment according to either metric (Recalling Sentences or Core Language). Functional MRI results indicated greater left hemisphere lateralization within significantly activated regions in the LI2 group. Structural language abilities were not meaningfully associated with either social abilities or lifetime ADHD symptoms in LI2 subgroups, further suggesting the presence of structural language impairment. Findings indicate the presence of persistent structural language difficulty even in the absence of ASD symptoms in some individuals within the LAD1 group and unique patterns of language-related neural specialization for language function in LI2 relative to LN3.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastorno del Espectro Autista / Trastornos del Desarrollo del Lenguaje Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Autístico / Trastorno del Espectro Autista / Trastornos del Desarrollo del Lenguaje Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Neuroimage Clin Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos