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Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study.
Zeng, Xiaoqi; Jiang, Shanshan; Ruan, Simin; Zhu, Lijun; Lian, Huining; Liu, Minfeng; Guo, Zhaoze; Guo, Jingyun; Ye, Changsheng; Cheng, Yunjiu; Dong, Jianyu.
Afiliación
  • Zeng X; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China.
  • Jiang S; Institute of Hematological Research, Shaanxi Provincial People's Hospital, Xi'an, 710000, China.
  • Ruan S; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China.
  • Zhu L; Department of Ultrasonography, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
  • Lian H; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China.
  • Liu M; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China.
  • Guo Z; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China.
  • Guo J; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China.
  • Ye C; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China. smuyecs@163.com.
  • Cheng Y; Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510700, China. chyj@mail.sysu.edu.cn.
  • Dong J; Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University, No.1838 North Guangzhou Avenue, Guangzhou, 510515, China. djypumc@163.com.
BMC Cancer ; 22(1): 534, 2022 May 12.
Article en En | MEDLINE | ID: mdl-35549892
BACKGROUND: Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain. METHODS: Data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort of middle-aged women, were used to investigate the association of individual and combined cardiovascular risk factors with breast cancer. Cox proportional hazards models were applied to calculate the hazard ratio (HR) and 95% confidence intervals (CI). RESULTS: A total of 7501 women were included. During a mean follow-up of 19.7 years, 576 women were diagnosed with breast cancer. White women and premenopausal status were independently associated with increased risk of breast cancer. Of the individual cardiovascular risk factors, only obesity was independently associated with an increased risk of breast cancer (HR 1.29, 95% CI 1.04-1.61). Compared with women without cardiovascular risk factors, women having three or greater, but not those with fewer than three cardiovascular risk factors, had a significantly higher risk of developing breast cancer (HR 1.27, 95% CI 1.06-1.53). Subgroup analyses indicated that women with three or greater cardiovascular risk factors had higher risk of breast cancer among postmenopausal Black women, but not among premenopausal Black and White women. CONCLUSIONS: Combinations of cardiovascular risk factors are associated with increased risk of breast cancer in middle-aged women, especially in postmenopausal Black women. Joint interventions to modify cardiovascular risk factors could be used to prevent breast cancer in these higher-risk individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Enfermedades Cardiovasculares Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Enfermedades Cardiovasculares Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido