Nup50 plays more than one instrument.

Holzer, Guillaume; Antonin, Wolfram

Holzer, Guillaume; Antonin, Wolfram.

Afiliación

Holzer G; Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany.
Antonin W; Institute of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, Aachen, Germany.

Cell Cycle ; 21(17): 1785-1794, 2022 09.

Article en En | MEDLINE | ID: mdl-35549614

RESUMEN

Nup50 is nuclear pore complex component localized to the nuclear side of the pore and in the nucleoplasm. It has been characterized as an auxiliary factor in nuclear transport reactions. Our recent work indicates that it interacts with and stimulates RCC1, the sole guanine nucleotide exchange factor for the GTPase Ran. Here, we discuss how this interaction might contribute to Nup50 function in nuclear transport but also its other functions like control of gene expression, cell cycle and DNA damage repair.

Asunto(s)

Proteínas de Ciclo Celular; Proteínas Nucleares; Proteínas de Ciclo Celular/metabolismo; Núcleo Celular/metabolismo; Factores de Intercambio de Guanina Nucleótido/genética; Factores de Intercambio de Guanina Nucleótido/metabolismo; Proteínas Nucleares/metabolismo; Proteína de Unión al GTP ran/metabolismo

Palabras clave

DNA repair; Nup50; RCC1; cell cycle; nuclear pore assembly; nuclear trafficking; p27Kip1

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Proteínas de Ciclo Celular Idioma: En Revista: Cell Cycle Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos

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