Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency.

Cai, Ke; Wang, Feng; Lu, Jia-Quan; Shen, An-Na; Zhao, Shi-Min; Zang, Wei-Dong; Gui, Yong-Hao; Zhao, Jian-Yuan

Cai, Ke; Wang, Feng; Lu, Jia-Quan; Shen, An-Na; Zhao, Shi-Min; Zang, Wei-Dong; Gui, Yong-Hao; Zhao, Jian-Yuan.

Afiliación

Cai K; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.
Wang F; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.
Lu JQ; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.
Shen AN; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.
Zhao SM; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.
Zang WD; Key Laboratory of Reproduction Regulation of NPFPC, Fudan University, Shanghai, China.
Gui YH; School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Zhao JY; NHC Key Laboratory of Neonatal Diseases, Cardiovascular Center, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, and School of Life Sciences, Fudan University, Shanghai, China.

JACC Basic Transl Sci ; 7(4): 348-362, 2022 Apr.

Article en En | MEDLINE | ID: mdl-35540099

Palabras clave

ANP, atrial natriuretic peptide; BCAA, branched-chain amino acid; BNP, brain natriuretic peptide; DCM, dilated cardiomyopathy; ECHS1, short-chain enoyl-CoA hydratase 1; FA, fatty acid; HCM, hypertrophic cardiomyopathy; HFF, human foreskin fibroblast; IVSd, interventricular septum in end-diastole; IVSs, interventricular septum in end-systole; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal dimension in end-diastole; LVIDs, left ventricular internal dimension in end-systole; LVPWd, left ventricular posterior wall in end-diastole; LVPWs, left ventricular posterior wall in end-systole; NMN, nicotinamide mononucleotide; acetylation of H3K9; cardiomyopathy; enoyl-CoA hydratase 1; nicotinamide mononucleotide; p300; α-SMA, smooth muscle actin-α

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: JACC Basic Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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