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The surgical management of a patient with chronic renal failure and macrothrombocytopenia related to the MYH9 gene mutation: A case report.
Costa, Rafael Fiorese; Bucharles, Sérgio Gardano Elias; Kagueiama, Douglas Eiji; Kus, Cintia Pereira; Andrade, Ariane de Almeida; Dirschnabel, Acir José; de Araujo, Melissa Rodrigues; de Lima, Antonio Adilson Soares.
Afiliación
  • Costa RF; Department of Stomatology, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Bucharles SGE; Fundação de Amparo a Pesquisa em Enfermidades Renais e Metabólicas, Pró-Renal, Curitiba, PR, Brazil.
  • Kagueiama DE; Fundação de Amparo a Pesquisa em Enfermidades Renais e Metabólicas, Pró-Renal, Curitiba, PR, Brazil.
  • Kus CP; Fundação de Amparo a Pesquisa em Enfermidades Renais e Metabólicas, Pró-Renal, Curitiba, PR, Brazil.
  • Andrade AA; Fundação de Amparo a Pesquisa em Enfermidades Renais e Metabólicas, Pró-Renal, Curitiba, PR, Brazil.
  • Dirschnabel AJ; Fundação de Amparo a Pesquisa em Enfermidades Renais e Metabólicas, Pró-Renal, Curitiba, PR, Brazil.
  • de Araujo MR; Fundação de Amparo a Pesquisa em Enfermidades Renais e Metabólicas, Pró-Renal, Curitiba, PR, Brazil.
  • de Lima AAS; Department of Stomatology, Universidade Federal do Paraná, Curitiba, PR, Brazil.
Spec Care Dentist ; 42(6): 651-656, 2022 Nov.
Article en En | MEDLINE | ID: mdl-35537118
MYH9 disease is a rare genetic disorder in which there is a mutation in the gene for the non-muscle myosin heavy chain IIA. It initially causes macrothrombocytopenia followed by other clinical manifestations. When the patient reaches adulthood, he can develop chronic kidney failure. Thus, the risk of suffering a hemorrhage, difficulty in repairing and, infections increases in individuals with this disease. In addition, the use of drugs in these patients should be carefully evaluated. An adult patient sought dental care with a complaint associated with a tooth with advanced dental caries. He had severe thrombocytopenia (7000 platelets/mm3 ), hearing loss, and chronic kidney failure. The diagnosis of MYH9 disease was confirmed through genotyping. After clinical examination, extraction was planned. Local and systemic procedures were used to prevent hemorrhage, especially postoperatively. Although the patient had an infection at the surgical wound site and no episode of postoperative bleeding, the repair process occurred normally. The purpose of this article is to report the surgical management of a patient with MYH9 disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombocitopenia / Caries Dental / Pérdida Auditiva Sensorineural / Fallo Renal Crónico Límite: Adult / Humans / Male Idioma: En Revista: Spec Care Dentist Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombocitopenia / Caries Dental / Pérdida Auditiva Sensorineural / Fallo Renal Crónico Límite: Adult / Humans / Male Idioma: En Revista: Spec Care Dentist Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos