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Temporal properties of pain contrast enhancement using repetitive stimulation.
Szikszay, Tibor M; Adamczyk, Waclaw M; Lévénez, Juliette L M; Gouverneur, Philip; Luedtke, Kerstin.
Afiliación
  • Szikszay TM; Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), Institute of Health Sciences, Universität zu Lübeck, Luebeck, Germany.
  • Adamczyk WM; Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), Institute of Health Sciences, Universität zu Lübeck, Luebeck, Germany.
  • Lévénez JLM; Laboratory of Pain Research, Institute of Physiotherapy and Health Sciences, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
  • Gouverneur P; Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), Institute of Health Sciences, Universität zu Lübeck, Luebeck, Germany.
  • Luedtke K; Institute of Medical Informatics, University of Luebeck, Luebeck, Germany.
Eur J Pain ; 26(7): 1437-1447, 2022 08.
Article en En | MEDLINE | ID: mdl-35535976
BACKGROUND: Offset analgesia (OA) is characterized by a disproportionately large reduction in pain following a small decrease in noxious stimulation and is based on temporal pain contrast enhancement (TPCE). The underlying mechanisms of this phenomenon are still poorly understood. This study is aiming to investigate whether TPCE can also be induced by repetitive stimulation, i.e., by stimuli clearly separated in time. METHODS: A repetitive TPCE paradigm was induced in healthy, pain-free subjects (n = 33) using heat stimuli. Three different interstimulus intervals (ISIs) were used: 5, 15, and 25 s. All paradigms were contrasted with a control paradigm without temperature change. Participants continuously rated perceived pain intensity. In addition, electrodermal activity (EDA) was recorded as a surrogate measure of autonomic arousal. RESULTS: Temporal pain contrast enhancement was confirmed for ISI 5 s (p < 0.001) and ISI 15 s (p = 0.005) but not for ISI 25 s (p = 0.07), however, the magnitude of TPCE did not differ between ISIs (p = 0.11). A TPCE-like effect was also detected with increased EDA values. CONCLUSIONS: TPCE can be induced by repetitive stimulation. This finding may be explained by a combination of the mechanisms underlying the OA and a facilitated pain habituation. SIGNIFICANCE: This experiment shows for the first time that temporal contrast enhancement of pain can be elicited by stimuli that are clearly separated in time with an interstimulus interval below 25 s.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Analgesia Límite: Humans Idioma: En Revista: Eur J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Analgesia Límite: Humans Idioma: En Revista: Eur J Pain Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido