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A Comparison of Different Frailty Scores and Impact of Frailty on Outcome in Patients With Cirrhosis.
Singh, Surender; Taneja, Sunil; Tandon, Puneeta; Bansal, Akash; Gorsi, Ujjwal; Roy, Akash; De, Arka; Verma, Nipun; Premkumar, Madhumita; Duseja, Ajay; Dhiman, Radha K; Singh, Virendra.
Afiliación
  • Singh S; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Taneja S; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Tandon P; Division of Gastroenterology, University of Alberta, Edmonton, Canada.
  • Bansal A; Department of Radiodiagnosis, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Gorsi U; Department of Radiodiagnosis, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Roy A; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • De A; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Verma N; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Premkumar M; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Duseja A; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Dhiman RK; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
  • Singh V; Department of Hepatology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
J Clin Exp Hepatol ; 12(2): 398-408, 2022.
Article en En | MEDLINE | ID: mdl-35535083
Background & aims: There is no "gold standard" tool for the assessment of frailty in cirrhosis. This study compares Liver Frailty Index (LFI), Short Physical Performance Battery (SPPB), Fried Frailty Criteria (FFC), and Clinical Frailty Scale (CFS) for frailty assessment and ascertains its impact on predicting mortality and hospitalizations in a cohort of outpatients with cirrhosis. Methods: 116 patients were enrolled in this prospective observational cohort study. Frailty assessment was done using LFI, SPPB, FFC, and CFS. All patients were followed up for 6 months. The primary outcome was the first of either all-cause unplanned hospitalization or all-cause mortality occurring within 6 months of the study period. Results: 100 (86.2%) males and 16 (13.8%) females with a mean age of 50.2 (48.4-51.9, 95% CI) years were included. The most common cause of cirrhosis was alcoholic liver disease (47.4%) followed by hepatitis C (12.9%) and Nonalcoholic steatohepatitis (NASH) (10.3%). There was no significant difference in prevalence of frailty based on LFI (43.1%), FFC (36.2%), CFS (44%), and SPPB (47.4%) (P > 0.05). Frail patients had worse outcomes compared to the Not frail group. At 6 months, the mortality rate in Frail patients was 42% versus 1.5% for the Not frail; hospitalization in Frail patients occurred in 92% versus 6% in the Not frail. On multivariable analysis, independent predictors of mortality were Frailty [OR 14 (1.4-54.2)], alcohol-related cirrhosis [OR 4.2 (1.1-16.3)], Child-Turcotte-Pugh (CTP) [OR 2.1 (1.4-2.9)] and Chronic liver disease questionnaire (CLDQ) [OR 0.1 (0.1-0.4)] scores. Conclusions: LFI, SPPB, FFC, and CFS are comparable in frailty assessment in patients with cirrhosis. Importantly, comparability of the commonly used scores for frailty assessment and prediction of hospitalization and mortality allows flexibility for clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Clin Exp Hepatol Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: India

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Clin Exp Hepatol Año: 2022 Tipo del documento: Article País de afiliación: India Pais de publicación: India