Your browser doesn't support javascript.
loading
Markers of ventricular repolarization and overall mortality in sleep disordered breathing.
Patel, Salma I; Zareba, Wojciech; LaFleur, Bonnie; Couderc, Jean-Phillipe; Xia, Xiaojuan; Woosley, Raymond; Patel, Imran Y; Combs, Daniel; Mashaqi, Saif; Quan, Stuart F; Parthasarathy, Sairam.
Afiliación
  • Patel SI; UAHS Center for Sleep and Circadian Sciences, University of Arizona, USA; Division of Pulmonary, Allergy, Critical Care Medicine and Sleep Medicine, University of Arizona College of Medicine, Tucson, USA. Electronic address: salmapatel@email.arizona.edu.
  • Zareba W; Clinical Cardiovascular Research Center, University of Rochester Medical Center, USA.
  • LaFleur B; UAHS Center for Biomedical Informatics and Biostatistics, University of Arizona, USA; BIO5, University of Arizona, USA; R. Ken Coit College of Pharmacy University of Arizona, USA.
  • Couderc JP; Clinical Cardiovascular Research Center, University of Rochester Medical Center, USA.
  • Xia X; Clinical Cardiovascular Research Center, University of Rochester Medical Center, USA.
  • Woosley R; Division of Clinical Data Analytics and Decision Support, University of Arizona College of Medicine, Phoenix, USA.
  • Patel IY; UAHS Center for Sleep and Circadian Sciences, University of Arizona, USA; Division of Pulmonary, Allergy, Critical Care Medicine and Sleep Medicine, University of Arizona College of Medicine, Tucson, USA.
  • Combs D; UAHS Center for Sleep and Circadian Sciences, University of Arizona, USA; Department of Pediatrics, University of Arizona College of Medicine, Tucson, USA.
  • Mashaqi S; UAHS Center for Sleep and Circadian Sciences, University of Arizona, USA; Division of Pulmonary, Allergy, Critical Care Medicine and Sleep Medicine, University of Arizona College of Medicine, Tucson, USA.
  • Quan SF; UAHS Center for Sleep and Circadian Sciences, University of Arizona, USA; Division of Pulmonary, Allergy, Critical Care Medicine and Sleep Medicine, University of Arizona College of Medicine, Tucson, USA; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School
  • Parthasarathy S; UAHS Center for Sleep and Circadian Sciences, University of Arizona, USA; Division of Pulmonary, Allergy, Critical Care Medicine and Sleep Medicine, University of Arizona College of Medicine, Tucson, USA.
Sleep Med ; 95: 9-15, 2022 07.
Article en En | MEDLINE | ID: mdl-35533628
INTRODUCTION: Variability and prolongation of ventricular repolarization - measured by changes in QT interval and QT variability are independently associated with ventricular arrhythmias, sudden death, and mortality but such studies did not examine the role of sleep-disordered breathing. We aimed to determine whether sleep-disordered breathing moderated the association between measures of ventricular repolarization and overall mortality. METHODS: Eight hundred participants were randomly selected from each of the following four groups in the Sleep Heart Health Study: mild, moderate, severe or no sleep disordered breathing (n = 200 each). Overnight electrocardiograms were analyzed for QTc duration and QT variability (standard deviation of QT intervals, normalized QT interval variance and the short-term interval beat-to-beat QT variability). Cox proportional hazards penalized regression modeling was used to identify predictors of mortality. RESULTS: Eight hundred of 5600 participants were randomly selected. The participants (68 ± 10 years; 56.8% male) were followed for an average of 8.2 years during which time 222 (28.4%) died. QTc, SDQT, and QTVN were associated with the presence of SDB (p = 0.002, p = 0.014, and p = 0.024, respectively). After adjusting for covariates, the presence of sleep-disordered breathing did not moderate the association between QTc length, QT variability and mortality (p > 0.05). CONCLUSION: Sleep-disordered breathing was associated with some measures of ventricular repolarization. However, sleep-disordered breathing was not an effect modifier for the relationship between QTc and QT variability and mortality.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Síndromes de la Apnea del Sueño Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arritmias Cardíacas / Síndromes de la Apnea del Sueño Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sleep Med Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos