ALT, alanine aminotransferase; Breast cancer; CCK-8, cell counting kit-8; CRE, creatinine; Chemotherapy; DOX, doxorubicin; DOX@PDA, DOX-loaded PDA nanoparticles; DTT, dithiothreitol; EDC, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide; ELISA, enzyme-linked immunosorbent assay; FBS, fetal bovine serum; FDA, fluorescein diacetate; H&E, Hematoxylin and Eosin; HA, hyaluronic acid; HA-SH, thiolated hyaluronic acid; Hydrogel; Immunotherapy; Intratumoral injection; LPS, lipopolysaccharide; Metastasis; NHS, N-hydroxysuccinimide; NIR, near-infrared; PDA, polydopamine; PI, propidium iodide; PTT, photothermal therapy; Photothermal; Polydopamine; RBC, red blood cells; SEM, scanning electron microscope; Tunel, terminal deoxynucleotidyl transferase dUTP nick end labeling; WBC, white blood cells