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Inflammatory, Oxidative Stress, and Cardiac Damage Biomarkers and Radiation-Induced Fatigue in Breast Cancer Survivors.
Vasbinder, Alexi; Thompson, Hilaire; Zaslavksy, Oleg; Heckbert, Susan R; Saquib, Nazmus; Shadyab, Aladdin H; Chlebowski, Rowan T; Warsinger Martin, Lisa; Paskett, Electra D; Reding, Kerryn W.
Afiliación
  • Vasbinder A; Department of Biobehavioral Nursing and Health Informatics, School of Nursing, 49462University of Washington, Seattle, WA, USA.
  • Thompson H; Department of Biobehavioral Nursing and Health Informatics, School of Nursing, 49462University of Washington, Seattle, WA, USA.
  • Zaslavksy O; Department of Biobehavioral Nursing and Health Informatics, School of Nursing, 49462University of Washington, Seattle, WA, USA.
  • Heckbert SR; Department of Epidemiology, School of Public Health, 49462University of Washington, Seattle, WA, USA.
  • Saquib N; Research Unit, College of Medicine, 473046Sulaiman AlRajhi University, Al Bukayriyah, Saudi Arabia.
  • Shadyab AH; Herbert Wertheim School of Public Health and Human Longevity Science, 8784University of California, San Diego, CA, USA.
  • Chlebowski RT; 117316Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Warsinger Martin L; Division of Cardiology, School of Medicine and Health Sciences, 43989George Washington University, Washington, DC, USA.
  • Paskett ED; Department of Medicine, Comprehensive Cancer Center, 549472The Ohio State University, Columbus, OH, USA.
  • Reding KW; Department of Biobehavioral Nursing and Health Informatics, School of Nursing, 49462University of Washington, Seattle, WA, USA.
Biol Res Nurs ; 24(4): 472-483, 2022 10.
Article en En | MEDLINE | ID: mdl-35527686
PURPOSE: Studies examining biomarkers associated with fatigue in breast cancer survivors treated with radiation are limited. Therefore, we examined the longitudinal association between serum biomarkers and post-breast cancer fatigue in survivors treated with radiation: [oxidative stress] 8-hydroxyguanosine, myeloperoxidase; [inflammation] interleukin-6 (IL-6), c-reactive protein, growth differentiation factor-15 (GDF-15), placental growth factor, transforming growth factor-beta, [cardiac damage] cystatin-C, troponin-I. METHODS: In a secondary analysis, we included participants from the Women's Health Initiative if they had: a previous breast cancer diagnosis (stages I-III), no prior cardiovascular diseases, pre-and post-breast cancer serum samples drawn approximately 3 years apart, and fatigue measured using the Short-Form 36 vitality subscale at both serum collections. Biomarkers were measured using ELISA or RT-qPCR and modeled as the log2 post-to pre-breast cancer ratio. RESULTS: Overall, 180 women with a mean (SD) age of 67.0 (5.5) years were included. The mean (SD) vitality scores were 66.2 (17.2) and 59.7 (19.7) pre- and post-breast cancer, respectively. Using multivariable weighted linear regression, higher biomarker ratios of cystatin-C, IL-6, and GDF-15 were associated with a lower vitality score (i.e., higher fatigue). For example, for each 2-fold difference in cystatin-C biomarker ratio, the vitality score was lower by 7.31 points (95% CI: -14.2, -0.45). CONCLUSION: Inflammatory and cardiac damage biomarkers are associated with fatigue in breast cancer survivors treated with radiation; however, these findings should be replicated in a larger sample. Biomarkers could be measured in clinical practice or assessed in risk prediction models to help identify patients at high risk for fatigue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Cistatinas / Supervivientes de Cáncer Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Biol Res Nurs Asunto de la revista: ENFERMAGEM / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Cistatinas / Supervivientes de Cáncer Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Biol Res Nurs Asunto de la revista: ENFERMAGEM / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos