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Silver nanowire loaded poly(ε-caprolactone) nanocomposite fibers as electroactive scaffolds for skeletal muscle regeneration.
Basturkmen, Berk; Ergene, Emre; Doganay, Doga; Yilgor Huri, Pinar; Unalan, Husnu Emrah; Aksoy, Eda Ayse.
Afiliación
  • Basturkmen B; Department of Polymer Science and Technology, Hacettepe University, Ankara 06800, Turkey.
  • Ergene E; Department of Biomedical Engineering, Ankara University, Ankara 06830, Turkey.
  • Doganay D; Department of Metallurgical and Materials Engineering, Middle East Technical University (METU), Ankara 06800, Turkey.
  • Yilgor Huri P; Department of Biomedical Engineering, Ankara University, Ankara 06830, Turkey.
  • Unalan HE; Department of Metallurgical and Materials Engineering, Middle East Technical University (METU), Ankara 06800, Turkey.
  • Aksoy EA; Department of Polymer Science and Technology, Hacettepe University, Ankara 06800, Turkey; Department of Basic Pharmaceutical Sciences, Hacettepe University, Ankara 06100, Turkey. Electronic address: edaayse@hacettepe.edu.tr.
Biomater Adv ; 134: 112567, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35527139
Volumetric muscle loss (VML) due to trauma and tumor removal operations affects millions of people every year. Although skeletal muscle has a natural repair mechanism, it cannot provide self-healing above a critical level of VML. In this study, nanocomposite aligned fiber scaffolds as support materials were developed for volumetric skeletal muscle regeneration. For this purpose, silver nanowire (Ag NW) loaded poly(ε-caprolactone) (PCL) nanocomposite fiber scaffolds (PCL-Ag NW) were prepared to mimic the aligned electroactive structure of skeletal muscle and provide topographic and conductive environment to modulate cellular behavior and orientation. A computer-aided rotational wet spinning (RWS) system was designed to produce high-yield fiber scaffolds. Nanocomposite fiber bundles with lengths of 50 cm were fabricated via this computer-aided RWS system. The morphological, chemical, thermal properties and biodegradation profiles of PCL and PCL-Ag NW nanocomposite fibers were characterized in detail. The proliferation behavior and morphology of C2C12 mouse myoblasts were investigated on PCL and PCL-Ag NW nanocomposite fibrous scaffolds with and without electrical stimulation. Significantly enhanced cell proliferation was observed on PCL-Ag NW nanocomposite fibers compared to neat PCL fibers with electrical stimulations of 1.5 V, 3 V and without electrical stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocompuestos / Nanocables Límite: Animals / Humans Idioma: En Revista: Biomater Adv Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocompuestos / Nanocables Límite: Animals / Humans Idioma: En Revista: Biomater Adv Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos