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MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FOXO1 protein complex.
Lin, Weimin; Wen, Xianyu; Li, Xuexin; Chen, Lei; Wei, Wei; Zhang, Lifan; Chen, Jie.
Afiliación
  • Lin W; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
  • Wen X; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
  • Li X; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
  • Chen L; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
  • Wei W; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
  • Zhang L; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.
  • Chen J; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China. Electronic address: jiechen@njau.edu.cn.
Biochem Biophys Res Commun ; 612: 126-133, 2022 07 05.
Article en En | MEDLINE | ID: mdl-35525196
CeRNA effect was an important regulation mode of miRNA mediated bio-activities, however, most of the researches of ceRNA were on ncRNAs synergetic with mRNAs, the exploration of ceRNA effect regulated mRNA interaction was still lack of. Besides, C/EBPα was one of the most crucial adipogenic regulators, which has been demonstrated to form a protein complex with FOXO1 to mediate AdipoQ expression. So that, we try to explore whether the ceRNA effect mediated the interaction of C/EBPα and FOXO1, and identified the key miRNAs of their ceRNA effect. In this paper, we found the ceRNA effect of C/EBPα and FOXO1 mediated their protein complex formation, furthermore regulated its transcriptional role for AdipoQ, thereby influencing pre-adipocytes adipogenesis. More importantly, we demonstrated that the miR-144 was the decisive factor that mediated the ceRNA effect of C/EBPα and FOXO1 to influence AdipoQ, thus regulated pre-adipocytes adipogenesis. This research will provide a new supplementary idea of the miRNA role in mediating coding RNA interaction that regulates pre-adipocyte adipogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Adipogénesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Adipogénesis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos