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Tetramethyl-phenanthroline copper complexes in the development of drugs to treat cancer: synthesis, characterization and cytotoxicity studies of a series of copper(II)-L-dipeptide-3,4,7,8-tetramethyl-phenanthroline complexes.
Alvarez, Natalia; Leite, Celisnolia M; Napoleone, Adriana; Mendes, Luis F S; Fernández, Carlos Y; Ribeiro, Ronny R; Ellena, Javier; Batista, Alzir A; Costa-Filho, Antonio J; Facchin, Gianella.
Afiliación
  • Alvarez N; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay.
  • Leite CM; Departamento de Química, Universidade Federal de São Carlos, CP 676, São Carlos, SP, 13565-905, Brazil.
  • Napoleone A; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay.
  • Mendes LFS; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil.
  • Fernández CY; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay.
  • Ribeiro RR; Departamento de Química, Centro Politécnico, Universidade Federal do Paraná, Curitiba, PR, Brazil.
  • Ellena J; Instituto de Física de São Carlos, Universidade de São Paulo, Av. do Trabalhador São-carlense 400, São Carlos, SP, 13566-590, Brazil.
  • Batista AA; Departamento de Química, Universidade Federal de São Carlos, CP 676, São Carlos, SP, 13565-905, Brazil.
  • Costa-Filho AJ; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, 14040-901, Brazil.
  • Facchin G; Facultad de Química, Universidad de la República, Av. General Flores 2124, Montevideo, Uruguay. gfacchin@fq.edu.uy.
J Biol Inorg Chem ; 27(4-5): 431-441, 2022 08.
Article en En | MEDLINE | ID: mdl-35524804
New compounds to fight cancer are needed due to cancer high incidence and lack of curative treatments for several classes of this disease. Metal-based coordination compounds offer a variety of molecules that can turn into drugs. Among them, coordination copper complexes are emerging as an attractive class of compounds for cancer treatment. A series of [Cu(L-dipeptide)(tmp)] (tmp = 3,4,7,8-tetramethyl-1,10-phenanthroline) complexes were synthesized and characterized in the solid state, including the determination of the crystalline structure of [Cu(Gly-Gly)(tmp)]·3.5 H2O and [Cu2Cl4(tmp)2]. The complexes were studied in solution, where the major species are also ternary ones. The lipophilicity of the complexes was determined and the binding to the DNA was evaluated, suggesting that it occurs in the DNA's major groove. The cytotoxicity of the complexes was evaluated on different cancer cell lines: human metastatic breast adenocarcinoma MDA-MB-231 (triple negative, ATCC: HTB-26), MCF-7 (ATCC: HTB-22), SK-BR-3 (ATCC: HTB-30), human lung epithelial carcinoma A549 (ATCC: CCL-185), cisplatin resistant-human ovarian carcinoma A2780cis (SIGMA) and nontumoral cell lines: MRC-5 (lung; ATCC: CCL-171) and MCF-10A (breast, ATCC: CRL-10317). [Cu(L-dipeptide)(tmp)] complexes are highly cytotoxic as compared to [Cu(L-dipeptide)(phenanthroline)] and cisplatin. Therefore, [Cu(L-dipeptide)(tmp)] complexes are promising candidates to have their in vivo activity further studied toward new treatments for triple negative breast cancer and other aggressive tumors for which there is no curative pharmacological treatment to the date.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejos de Coordinación / Neoplasias de la Mama Triple Negativas / Antineoplásicos Límite: Humans Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Uruguay Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejos de Coordinación / Neoplasias de la Mama Triple Negativas / Antineoplásicos Límite: Humans Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Uruguay Pais de publicación: Alemania