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Perspectives on Cognitive Phenotypes and Models of Vascular Disease.
Muratoglu, Selen C; Charette, Marc F; Galis, Zorina S; Greenstein, Adam S; Daugherty, Alan; Joutel, Anne; Kozel, Beth A; Wilcock, Donna M; Collins, Emily C; Sorond, Farzaneh A; Howell, Gareth R; Hyacinth, Hyacinth I; Lloyd, Kent K C; Stenmark, Kurt R; Boehm, Manfred; Kahn, Mark L; Corriveau, Roderick; Wells, Sara; Bussey, Timothy J; Sukoff Rizzo, Stacey J; Iruela-Arispe, M Luisa.
Afiliación
  • Muratoglu SC; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.C.M., M.F.C., Z.S.G.).
  • Charette MF; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.C.M., M.F.C., Z.S.G.).
  • Galis ZS; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (S.C.M., M.F.C., Z.S.G.).
  • Greenstein AS; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (A.S.G.).
  • Daugherty A; Saha Cardiovascular Research Center (A.D.), University of Kentucky, Lexington.
  • Joutel A; Institute of Psychiatry and Neurosciences of Paris, INSERM U1266, Université Paris Descartes, France (A.J.).
  • Kozel BA; Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (B.A.K., M.B.).
  • Wilcock DM; Sanders-Brown Center on Aging, Department of Neuroscience (D.M.W.), University of Kentucky, Lexington.
  • Collins EC; Eli Lilly and Company, Indianapolis, IN (E.C.C.).
  • Sorond FA; Division of Stroke and Neurocritical Care, Northwestern University Feinberg School of Medicine, Chicago, IL (F.A.S.).
  • Howell GR; The Jackson Laboratory, Bar Harbor, ME (G.R.H.).
  • Hyacinth HI; Graduate Program of Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA (G.R.H.).
  • Lloyd KKC; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH (H.I.H.).
  • Stenmark KR; Mutant Mouse Resource and Research Center (MMRRC) at the University of California, Davis (K.K.C.L.).
  • Boehm M; Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado, Denver (K.R.S.).
  • Kahn ML; Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (B.A.K., M.B.).
  • Corriveau R; Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia (M.L.K.).
  • Wells S; National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (R.C.).
  • Bussey TJ; Mary Lyon Centre, Harwell Campus, MRC Harwell Institute, Oxfordshire, United Kingdom (S.W.).
  • Sukoff Rizzo SJ; Translational Neuroscience Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (T.J.B.).
  • Iruela-Arispe ML; Department of Medicine-Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA (S.J.S.R.).
Arterioscler Thromb Vasc Biol ; 42(7): 831-838, 2022 07.
Article en En | MEDLINE | ID: mdl-35510549
Clinical investigations have established that vascular-associated medical conditions are significant risk factors for various kinds of dementia. And yet, we are unable to associate certain types of vascular deficiencies with specific cognitive impairments. The reasons for this are many, not the least of which are that most vascular disorders are multi-factorial and the development of vascular dementia in humans is often a multi-year or multi-decade progression. To better study vascular disease and its underlying causes, the National Heart, Lung, and Blood Institute of the National Institutes of Health has invested considerable resources in the development of animal models that recapitulate various aspects of human vascular disease. Many of these models, mainly in the mouse, are based on genetic mutations, frequently using single-gene mutations to examine the role of specific proteins in vascular function. These models could serve as useful tools for understanding the association of specific vascular signaling pathways with specific neurological and cognitive impairments related to dementia. To advance the state of the vascular dementia field and improve the information sharing between the vascular biology and neurobehavioral research communities, National Heart, Lung, and Blood Institute convened a workshop to bring in scientists from these knowledge domains to discuss the potential utility of establishing a comprehensive phenotypic cognitive assessment of a selected set of existing mouse models, representative of the spectrum of vascular disorders, with particular attention focused on age, sex, and rigor and reproducibility. The workshop highlighted the potential of associating well-characterized vascular disease models, with validated cognitive outcomes, that can be used to link specific vascular signaling pathways with specific cognitive and neurobehavioral deficits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia Vascular / Disfunción Cognitiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia Vascular / Disfunción Cognitiva Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos