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An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.
Tian, Guilian; Hui, May; Macchia, Desiree; Derdeyn, Pieter; Rogers, Alexandra; Hubbard, Elizabeth; Liu, Chengfeng; Vasquez, Jose J; Taniguchi, Lara; Bartas, Katrina; Carroll, Sean; Beier, Kevin T.
Afiliación
  • Tian G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Hui M; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Macchia D; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Derdeyn P; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA 92617, USA.
  • Rogers A; Interdepartmental Neuroscience Program, University of California, Irvine, Irvine, CA 92617, USA.
  • Hubbard E; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Liu C; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Vasquez JJ; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Taniguchi L; Interdepartmental Neuroscience Program, University of California, Irvine, Irvine, CA 92617, USA.
  • Bartas K; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA 92617, USA.
  • Carroll S; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
  • Beier KT; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA; Department
Cell Rep ; 39(5): 110775, 2022 05 03.
Article en En | MEDLINE | ID: mdl-35508124
Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a ventral tegmental area DA projection to the amygdala (VTADA→amygdala) for cocaine-induced anxiety but not cocaine reward or sensitization. Our rabies virus-mediated circuit mapping approach reveals a persistent elevation in spontaneous and task-related activity of inhibitory GABAergic cells from the bed nucleus of the stria terminalis (BNST) and downstream VTADA→amygdala cells that can be detected even after a single cocaine exposure. Activity in BNSTGABA→midbrain cells is related to cocaine-induced anxiety but not reward or sensitization, and silencing this projection prevents development of anxiety during protracted withdrawal after cocaine administration. Finally, we observe that VTADA→amygdala cells are strongly activated after a challenge exposure to cocaine and that activity in these cells is necessary and sufficient for reinstatement of cocaine place preference.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cocaína / Trastornos Relacionados con Cocaína Límite: Humans Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cocaína / Trastornos Relacionados con Cocaína Límite: Humans Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos