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Improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular disease: a randomized clinical trial.
Leitão, Renata; de Oliveira, Gustavo Vieira; Rezende, Cristina; Volino-Souza, Mônica; Mesquita, Jacilene; de Carvalho, Leandro Lara; Alvares, Thiago Silveira.
Afiliación
  • Leitão R; Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
  • de Oliveira GV; Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
  • Rezende C; Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
  • Volino-Souza M; Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
  • Mesquita J; Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil.
  • de Carvalho LL; Laboratory of Catalysis and Synthesis of Bioactivity Substances, Federal University of Rio de Janeiro, Estrada do Imburo, s/n, Macaé, 27979-000, RJ, Brazil.
  • Alvares TS; Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Federal University of Rio de Janeiro, Macaé Campus, Multidisciplinary Center UFRJ-Macaé, Estrada do Imburo, s/n, Macaé, RJ, 27979-000, Brazil. alvares@macae.ufrj.br.
Eur J Nutr ; 61(7): 3357-3366, 2022 Oct.
Article en En | MEDLINE | ID: mdl-35505122
PURPOSE: This study aimed to investigate the effects of AGE on microvascular reactivity, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in older individuals at high risk for cardiovascular disease (CVD). Urinary thiosulfate was also investigated as an indirect marker of endogenous hydrogen sulfide (H2S) synthesis. The study was conducted in a randomized, double-blind, crossover, and placebo-controlled way. METHODS: Twenty-eight participants (14 male), 67 ± 6 years old with CVD risk factors, ingested 2.4 g of AGE or placebo (PLA). Near-infrared spectroscopy evaluated tissue oxygen saturation (StO2) during a vascular occlusion test (30 s baseline, 5 min occlusion, and 2 min reperfusion). The upslope of StO2 signal after cuff release was calculated to measure microvascular reactivity. Urinary thiosulfate levels were measured using a high-performance liquid chromatography system. RESULTS: The upslope of StO2 was significantly faster after AGE (1.01 ± 0.37% s-1) intake compared to PLA (0.83 ± 0.35% s-1; P < 0.001; d = 0.50). Relative changes in Δ% SBP from pre- to post-AGE intake (- 5.17 ± 5.77%) was significantly different compared to Δ% PLA (0.32 ± 5.99%; P = 0.001; d = 0.93). No significant changes in urinary thiosulfate concentrations were observed between interventions. Moreover, no significant gender effect in any parameter assessed was found. CONCLUSION: This study demonstrated that a single dose of AGE improved microvascular reactivity in older adults at risk of CVD despite such an effect was not linked with urinary thiosulfate levels. This trial was registered at clinicaltrials.gov as NCT04008693 (May 19, 2020).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Ajo / Sulfuro de Hidrógeno Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Ajo / Sulfuro de Hidrógeno Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Aged / Humans / Male / Middle aged Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania