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Immunohistological study of the density and distribution of human penile neural tissue: gradient hypothesis.
Cepeda-Emiliani, Alfonso; Gándara-Cortés, Marina; Otero-Alén, María; García, Heidy; Suárez-Quintanilla, Juan; García-Caballero, Tomás; Gallego, Rosalía; García-Caballero, Lucía.
Afiliación
  • Cepeda-Emiliani A; Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain. alfonsomario.cepeda@rai.usc.es.
  • Gándara-Cortés M; Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • Otero-Alén M; Department of Pathology, University Clinical Hospital, Santiago de Compostela, Spain.
  • García H; Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.
  • Suárez-Quintanilla J; National Institute of Legal Medicine and Forensic Sciences of Colombia, Barranquilla, Colombia.
  • García-Caballero T; Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • Gallego R; Department of Morphological Sciences, School of Medicine and Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain.
  • García-Caballero L; Department of Pathology, University Clinical Hospital, Santiago de Compostela, Spain.
Int J Impot Res ; 35(3): 286-305, 2023 May.
Article en En | MEDLINE | ID: mdl-35501394
Immunohistological patterns of density and distribution of neural tissue in the human penis, including the prepuce, are not fully characterized, and effects of circumcision (partial or total removal of the penile prepuce) on penile sexual sensation are controversial. This study analyzed extra- and intracavernosal innervation patterns on the main penile axes using formalin-fixed, paraffin-embedded human adult and fetal penile tissues, single- and double-staining immunohistochemistry and a variety of neural and non-neural markers, with a special emphasis on the prepuce and potential sexual effects of circumcision. Immunohistochemical profiles of neural structures were determined and the most detailed immunohistological characterizations to date of preputial nerve supply are provided. The penile prepuce has a highly organized, dense, afferent innervation pattern that is manifest early in fetal development. Autonomically, it receives noradrenergic sympathetic and nitrergic parasympathetic innervation. Cholinergic nerves are also present. We observed cutaneous and subcutaneous neural density distribution biases across our specimens towards the ventral prepuce, including a region corresponding in the adult anatomical position (penis erect) to the distal third of the ventral penile aspect. We also describe a concept of innervation gradients across the longitudinal and transverse penile axes. Results are discussed in relation to the specialized literature. An argument is made that neuroanatomic substrates underlying unusual permanent penile sensory disturbances post-circumcision are related to heightened neural levels in the distal third of the ventral penile aspect, which could potentially be compromised by deep incisions during circumcision.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pene / Circuncisión Masculina Límite: Adult / Humans / Male Idioma: En Revista: Int J Impot Res Asunto de la revista: MEDICINA REPRODUTIVA / UROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pene / Circuncisión Masculina Límite: Adult / Humans / Male Idioma: En Revista: Int J Impot Res Asunto de la revista: MEDICINA REPRODUTIVA / UROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido