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Partial resistance to citalopram in a Wistar-Kyoto rat model of depression: An evaluation using resting-state functional MRI and graph analysis.
Li, Qi; Zhao, Wentao; Liu, Sha; Zhao, Yu; Pan, Weixing; Wang, Xiao; Liu, Zhifen; Xu, Yong.
Afiliación
  • Li Q; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China; Janelia Research Campus, Howard Hughes M
  • Zhao W; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China.
  • Liu S; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China.
  • Zhao Y; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China; National Key Disciplines, Key Laboratory
  • Pan W; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147, USA.
  • Wang X; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China.
  • Liu Z; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China. Electronic address: liuzhifen5518@163.co
  • Xu Y; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Shanxi Provincial Key Laboratory of Brain Science and Neuropsychiatric Diseases, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Mental Health, Shanxi Medi
J Psychiatr Res ; 151: 242-251, 2022 07.
Article en En | MEDLINE | ID: mdl-35500452
Wistar-Kyoto (WKY) rats as an endogenous depression model partially lack a response to classic selective serotonin reuptake inhibitors (SSRIs). Thus, this strain has the potential to be established as a model of treatment-resistant depression (TRD). However, the SSRI resistance in WKY rats is still not fully understood. In this study, WKY and control rats were subjected to a series of tests, namely, a forced swim test (FST), a sucrose preference test (SPT), and an open field test (OFT), and were scanned in a 7.0-T MRI scanner before and after three-week citalopram or saline administration. Behavioral results demonstrated that WKY rats had increased immobility in the FST and decreased sucrose preference in the SPT and central time spent in the OFT. However, citalopram did not improve immobility in the FST. The amplitude of low-frequency fluctuation (ALFF) analysis showed regional changes in the striatum and hippocampus of WKY rats. However, citalopram partially reversed the ALFF value in the dorsal part of the two regions. Functional connectivity (FC) analysis showed that FC strengths were decreased in WKY rats compared with controls. Nevertheless, citalopram partially increased FC strengths in WKY rats. Based on FC, global graph analysis demonstrated decreased network efficiency in WKY + saline group compared with control + saline group, but citalopram showed weak network efficiency improvement. In conclusion, resting-state fMRI results implied widely affected brain function at both regional and global levels in WKY rats. Citalopram had only partial effects on these functional changes, indicating a potential treatment resistance mechanism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citalopram / Trastorno Depresivo Resistente al Tratamiento Límite: Animals / Humans Idioma: En Revista: J Psychiatr Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citalopram / Trastorno Depresivo Resistente al Tratamiento Límite: Animals / Humans Idioma: En Revista: J Psychiatr Res Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido