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Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial.
Granfeldt, Asger; Sindberg, Birthe; Isbye, Dan; Kjærgaard, Jesper; Kristensen, Camilla M; Darling, Søren; Zwisler, Stine T; Fisker, Stine; Schmidt, Jens Christian; Kirkegaard, Hans; Grejs, Anders M; Rossau, Jørgen R G; Larsen, Jacob M; Rasmussen, Bodil S; Riddersholm, Signe; Iversen, Kasper; Schultz, Martin; Nielsen, Jakob L; Løfgren, Bo; Lauridsen, Kasper G; Sølling, Christoffer; Pælestik, Kim; Kjærgaard, Anders G; Due-Rasmussen, Dorte; Folke, Fredrik; Charlot, Mette G; Jepsen, Rikke Malene H G; Wiberg, Sebastian; Høybye, Maria; Holmberg, Mathias J; Andersen, Lars W.
Afiliación
  • Granfeldt A; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
  • Sindberg B; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Isbye D; Department of Anesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Kjærgaard J; Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Kristensen CM; Department of Anesthesia, Centre of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Darling S; Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.
  • Zwisler ST; Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.
  • Fisker S; Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.
  • Schmidt JC; Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.
  • Kirkegaard H; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Grejs AM; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Rossau JRG; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
  • Larsen JM; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
  • Rasmussen BS; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Anesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.
  • Riddersholm S; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark.
  • Iversen K; Department of Emergency Medicine, Herlev and Gentofte University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Schultz M; Department of Internal Medicine, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
  • Nielsen JL; Unit of Clinical Simulation and Education, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
  • Løfgren B; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark.
  • Lauridsen KG; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Department of Anesthesiology and Critical Care Medicine, Children'
  • Sølling C; Department of Anesthesiology and Intensive Care, Viborg Regional Hospital, Viborg, Denmark.
  • Pælestik K; Department of Anesthesiology and Intensive Care, Viborg Regional Hospital, Viborg, Denmark.
  • Kjærgaard AG; Department of Anesthesiology and Intensive Care, Horsens Regional Hospital, Horsens, Denmark.
  • Due-Rasmussen D; Department of Anesthesiology and Intensive Care, Horsens Regional Hospital, Horsens, Denmark.
  • Folke F; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark; Copenhagen Emergency Medical Services, University of Copenhagen, Copenhagen, Denmark.
  • Charlot MG; Department of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
  • Jepsen RMHG; Department of Anesthesiology, Zealand University Hospital, Køge, Denmark.
  • Wiberg S; Department of Anesthesiology, Zealand University Hospital, Køge, Denmark.
  • Høybye M; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Holmberg MJ; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Anesthesiology and Intensive Care, Randers Regional Hospital, Randers, Denmark.
  • Andersen LW; Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark; Research Center for Emergency Medicine, Department of Clinical Medicine and Emergency Department, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Prehospital Emergency Medical Services, C
Resuscitation ; 175: 67-71, 2022 06.
Article en En | MEDLINE | ID: mdl-35490936
OBJECTIVE: The primary results from the Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest (VAM-IHCA) trial have previously been reported. The objective of the current manuscript is to report long-term outcomes. METHODS: The VAM-IHCA trial was a multicenter, randomized, double-blind, placebo-controlled trial conducted at ten hospitals in Denmark. Adult patients (age ≥ 18 years) were eligible for the trial if they had an in-hospital cardiac arrest and received at least one dose of epinephrine during resuscitation. The trial drugs consisted of 40 mg methylprednisolone (Solu-Medrol®, Pfizer) and 20 IU of vasopressin (Empressin®, Amomed Pharma GmbH) given as soon as possible after the first dose of epinephrine. This manuscript report outcomes at 6 months and 1 year including survival, survival with favorable neurological outcome, and health-related quality of life. RESULTS: 501 patients were included in the analysis. At 1 year, 15 patients (6.3%) in the intervention group and 22 patients (8.3%) in the placebo group were alive corresponding to a risk ratio of 0.76 (95% CI, 0.41-1.41). A favorable neurologic outcome at 1 year, based on the Cerebral Performance Category score, was observed in 14 patients (5.9%) in the intervention group and 20 patients (7.6%) in the placebo group (risk ratio, 0.78 [95% CI, 0.41-1.49]. No differences existed between groups for favorable neurological outcome and health-related quality of life at either 6 months or 1 year. CONCLUSIONS: Administration of vasopressin and methylprednisolone, compared with placebo, in patients with in-hospital cardiac arrest did not improve long-term outcomes in this trial.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reanimación Cardiopulmonar / Paro Cardíaco Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Adolescent / Adult / Humans Idioma: En Revista: Resuscitation Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reanimación Cardiopulmonar / Paro Cardíaco Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Adolescent / Adult / Humans Idioma: En Revista: Resuscitation Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Irlanda