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Influence of the amount of skeletal muscle mass on rocuronium-induced neuromuscular block.
Doo, A Ram; Lee, Jun Ho; Lee, Youngkwan; Ko, Seonghoon.
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  • Doo AR; Department of Anaesthesiology and Pain Medicine, Jeonbuk National University Medical School, Jeonju, South Korea; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
  • Lee JH; Department of Anaesthesiology and Pain Medicine, Jeonbuk National University Medical School, Jeonju, South Korea; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
  • Lee Y; Department of Anaesthesiology and Pain Medicine, Jeonbuk National University Medical School, Jeonju, South Korea.
  • Ko S; Department of Anaesthesiology and Pain Medicine, Jeonbuk National University Medical School, Jeonju, South Korea; Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea. Electronic address: shk
Anaesth Crit Care Pain Med ; 41(4): 101086, 2022 08.
Article en En | MEDLINE | ID: mdl-35490864
OBJECTIVE: To evaluate the effects of skeletal muscle mass on the rocuronium-induced neuromuscular block. DESIGN: A prospective, double-blinded, observational study. SETTING: A tertiary care university hospital. POPULATION: One hundred one patients aged 18-65 years who were scheduled to undergo major surgery lasting more than 1 h under general anaesthesia. METHODS: All participants underwent body composition analysis before anaesthesia and were allocated into two groups; the muscular and non-muscular group, according to skeletal muscle mass. During anaesthesia induction, rocuronium 1.0 mg kg-1 of total body weight was injected followed by neuromuscular monitoring using train-of-four stimulation every 15 s. MAIN OUTCOME MEASURES: The onset time of rocuronium included the elapsed time from the rocuronium injection until 95% depression of first twitch (T1) and the time to no response to TOF stimulation. The duration was evaluated as the elapsed time from the rocuronium injection to 25% recovery of the final T1 (TDUR25), and the time to the reappearance of T1 (TTOF1) and T4 (TTOF4). These pharmacologic data were compared between two groups. RESULTS: There was no significant difference in the onset time of rocuronium between the two groups. However, TDUR25 (min) was significantly shorter in the muscular group than in the non-muscular group (p = 0.035 and p = 0.014 in males and females, respectively). TTOF1 and TTOF4 were also shorter in the muscular group than in the non-muscular group. CONCLUSIONS: Total body weight-based dosing of rocuronium might prolong the neuromuscular relaxation effect in patients with a small amount of skeletal muscle.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuromusculares no Despolarizantes / Bloqueo Neuromuscular Tipo de estudio: Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Anaesth Crit Care Pain Med Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuromusculares no Despolarizantes / Bloqueo Neuromuscular Tipo de estudio: Observational_studies Límite: Female / Humans / Male Idioma: En Revista: Anaesth Crit Care Pain Med Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Francia