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Dammarane-type triterpenoids from Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) and their AMPK activation effect in 3T3-L1 cells.
Dinh, Thi Thanh Thuy; Nguyen, Thi Thu; Ngo, Huy Trung; Tran, Thi Hien; Le, Ba Vinh; Pham, Thanh Huyen; Pham, Ha Thanh Tung; Pham, Thanh Ky; Do, Thi Ha.
Afiliación
  • Dinh TTT; National Institute of Medicinal Materials (NIMM), 3B Quang Trung, Hoan Kiem, Hanoi, Viet Nam; National Hospital for Tropical Diseases, Dong Anh, Hanoi, Viet Nam.
  • Nguyen TT; National Institute of Medicinal Materials (NIMM), 3B Quang Trung, Hoan Kiem, Hanoi, Viet Nam.
  • Ngo HT; National Institute of Medicinal Materials (NIMM), 3B Quang Trung, Hoan Kiem, Hanoi, Viet Nam.
  • Tran TH; Thai Binh University Medicine and Pharmacy, 373 Ly Bon, Thai Binh, Viet Nam.
  • Le BV; College of Pharmacy, Korea University, Sejong, 47236, Republic of Korea; Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet Cau Giay, Hanoi, Viet Nam.
  • Pham TH; National Institute of Medicinal Materials (NIMM), 3B Quang Trung, Hoan Kiem, Hanoi, Viet Nam.
  • Pham HTT; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi, Viet Nam.
  • Pham TK; Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi, Viet Nam.
  • Do TH; National Institute of Medicinal Materials (NIMM), 3B Quang Trung, Hoan Kiem, Hanoi, Viet Nam. Electronic address: hado.nimms@gmail.com.
Phytochemistry ; 200: 113218, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35490775
Bioassay-guided fractionation of the 80% ethanol extract of Gynostemma compressum X. X. Chen & D. R. Liang (Cucurbitaceae) resulted in the isolation and identification of eight undescribed triterpenoids, gycomol VN1, gycomol VN2, and gycomosides VN1-6 from the bioactive n-butanol fraction. The structures of these compounds were elucidated by one- and two-dimensional nuclear magnetic resonance spectroscopy, high-resolution electrospray ionisation mass spectrometry, and chemical methods. All isolated compounds were evaluated for their 5'-adenosine monophosphate-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) activation effects on 3T3-L1 cells. Importantly, gycomol VN2, gycomoside VN1, and gycomosides VN3-5 activated the phosphorylation of AMPK and its downstream substrate ACC in 3T3-L1 cells at a dose of 10 µM. These effects imply that the activation of AMPK and ACC by active compounds from G. compressum has considerable potential for the prevention of obesity and its related disorders by activating AMPK signaling pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Cucurbitaceae Límite: Animals Idioma: En Revista: Phytochemistry Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triterpenos / Cucurbitaceae Límite: Animals Idioma: En Revista: Phytochemistry Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido